| Team: | Louisville | Rating: | -1.1563 | Average Socre: | 67.3125 |
| Conference: | ACC | ||||
| Wins: | 13 | Losses: | 19 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 212 | Southern (17 - 14) | 72 | 60 | ||
| 11/12/2021 | L | 77 | Furman (22 - 12) | 72 | 80 | ||
| 11/15/2021 | W | 121 | Navy (21 - 11) | 77 | 60 | ||
| 11/20/2021 | W | 215 | Detroit Mercy (14 - 15) | 73 | 67 | ||
| 11/25/2021 | W | at | 108 | Mississippi St. (18 - 15) | 72 | 58 | Nassau, Bahamas |
| 11/27/2021 | W | 163 | Maryland (15 - 17) | 63 | 55 | Nassau, Bahamas | |
| 12/01/2021 | L | at | 49 | Michigan St. (22 - 12) | 64 | 73 | |
| 12/04/2021 | W | at | 249 | N.C. State (11 - 21) | 73 | 68 | |
| 12/10/2021 | L | 172 | DePaul (15 - 16) | 55 | 62 | ||
| 12/14/2021 | W | 174 | Southeastern Louisiana (19 - 14) | 86 | 60 | ||
| 12/18/2021 | L | at | 144 | Western Kentucky (19 - 13) | 72 | 82 | |
| 12/29/2021 | W | 66 | Wake Forest (23 - 9) | 73 | 69 | ||
| 01/02/2022 | W | at | 266 | Georgia Tech (12 - 20) | 67 | 64 | |
| 01/05/2022 | W | 245 | Pittsburgh (11 - 21) | 75 | 72 | ||
| 01/08/2022 | L | at | 133 | Florida St. (17 - 14) | 70 | 79 | |
| 01/12/2022 | L | 249 | N.C. State (11 - 21) | 63 | 79 | ||
| 01/15/2022 | L | at | 245 | Pittsburgh (11 - 21) | 53 | 65 | |
| 01/19/2022 | W | 251 | Boston College (13 - 20) | 67 | 54 | ||
| 01/22/2022 | L | 61 | Notre Dame (22 - 10) | 70 | 82 | ||
| 01/24/2022 | L | at | 100 | Virginia (19 - 13) | 52 | 64 | |
| 01/29/2022 | L | 8 | Duke (28 - 6) | 65 | 74 | ||
| 02/01/2022 | L | 37 | North Carolina (24 - 9) | 83 | 90 | ||
| 02/05/2022 | L | at | 164 | Syracuse (16 - 17) | 69 | 92 | |
| 02/09/2022 | L | at | 61 | Notre Dame (22 - 10) | 57 | 63 | |
| 02/16/2022 | L | 46 | Miami FL (23 - 10) | 63 | 70 | ||
| 02/19/2022 | W | 156 | Clemson (17 - 16) | 70 | 61 | ||
| 02/21/2022 | L | at | 37 | North Carolina (24 - 9) | 63 | 70 | |
| 02/26/2022 | L | at | 66 | Wake Forest (23 - 9) | 77 | 99 | |
| 03/01/2022 | L | at | 68 | Virginia Tech (23 - 12) | 43 | 75 | |
| 03/05/2022 | L | 100 | Virginia (19 - 13) | 61 | 71 | ||
| 03/08/2022 | W | 266 | Georgia Tech (12 - 20) | 84 | 74 | Brooklyn, NY | |
| 03/09/2022 | L | at | 100 | Virginia (19 - 13) | 50 | 51 | Brooklyn, NY |