| Team: | Wake Forest | Rating: | 6.4375 | Average Socre: | 79.4688 |
| Conference: | ACC | ||||
| Wins: | 23 | Losses: | 9 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | W | 346 | William & Mary (5 - 27) | 77 | 59 | ||
| 11/12/2021 | W | 273 | Western Carolina (11 - 21) | 87 | 75 | ||
| 11/17/2021 | W | 353 | Charleston Southern (6 - 25) | 95 | 59 | ||
| 11/20/2021 | W | 289 | North Carolina A&T (12 - 20) | 87 | 63 | ||
| 11/23/2021 | W | 274 | Kennesaw St. (13 - 18) | 92 | 61 | ||
| 11/26/2021 | W | 344 | Oregon St. (3 - 28) | 80 | 77 | Niceville, FL | |
| 11/27/2021 | L | 39 | LSU (22 - 11) | 61 | 75 | Niceville, FL | |
| 11/30/2021 | W | 193 | Northwestern (15 - 16) | 77 | 73 | ||
| 12/04/2021 | W | at | 68 | Virginia Tech (23 - 12) | 80 | 61 | |
| 12/11/2021 | W | 218 | USC Upstate (14 - 16) | 79 | 53 | ||
| 12/14/2021 | W | 181 | VMI (16 - 15) | 77 | 70 | ||
| 12/17/2021 | W | 138 | Charlotte (17 - 14) | 82 | 79 | Charlotte, NC | |
| 12/29/2021 | L | at | 210 | Louisville (13 - 19) | 69 | 73 | |
| 01/01/2022 | L | at | 46 | Miami FL (23 - 10) | 84 | 92 | |
| 01/04/2022 | W | 133 | Florida St. (17 - 14) | 76 | 54 | ||
| 01/08/2022 | W | 164 | Syracuse (16 - 17) | 77 | 74 | ||
| 01/12/2022 | L | 8 | Duke (28 - 6) | 64 | 76 | ||
| 01/15/2022 | W | at | 100 | Virginia (19 - 13) | 63 | 55 | |
| 01/19/2022 | W | at | 266 | Georgia Tech (12 - 20) | 80 | 64 | |
| 01/22/2022 | W | 37 | North Carolina (24 - 9) | 98 | 76 | ||
| 01/24/2022 | W | 251 | Boston College (13 - 20) | 87 | 57 | ||
| 01/29/2022 | L | at | 164 | Syracuse (16 - 17) | 72 | 94 | |
| 02/02/2022 | W | 245 | Pittsburgh (11 - 21) | 91 | 75 | ||
| 02/05/2022 | W | at | 133 | Florida St. (17 - 14) | 68 | 60 | |
| 02/09/2022 | W | at | 249 | N.C. State (11 - 21) | 69 | 51 | |
| 02/12/2022 | L | 46 | Miami FL (23 - 10) | 72 | 76 | ||
| 02/15/2022 | L | at | 8 | Duke (28 - 6) | 74 | 76 | |
| 02/19/2022 | W | 61 | Notre Dame (22 - 10) | 79 | 74 | ||
| 02/23/2022 | L | at | 156 | Clemson (17 - 16) | 69 | 80 | |
| 02/26/2022 | W | 210 | Louisville (13 - 19) | 99 | 77 | ||
| 03/02/2022 | W | 249 | N.C. State (11 - 21) | 101 | 76 | ||
| 03/09/2022 | L | 251 | Boston College (13 - 20) | 77 | 82 | Brooklyn, NY |