| Team: | Pittsburgh | Rating: | -3.0938 | Average Socre: | 61.5313 |
| Conference: | ACC | ||||
| Wins: | 11 | Losses: | 21 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | 244 | The Citadel (13 - 18) | 63 | 78 | ||
| 11/12/2021 | L | at | 130 | West Virginia (16 - 17) | 59 | 74 | |
| 11/16/2021 | W | 85 | UNC Wilmington (23 - 9) | 59 | 51 | ||
| 11/19/2021 | W | 47 | Towson (25 - 8) | 63 | 59 | ||
| 11/24/2021 | L | 134 | Vanderbilt (17 - 16) | 52 | 68 | ||
| 11/27/2021 | L | 176 | UMBC (18 - 14) | 77 | 87 | ||
| 11/30/2021 | L | 179 | Minnesota (13 - 17) | 53 | 54 | ||
| 12/03/2021 | L | at | 100 | Virginia (19 - 13) | 56 | 57 | |
| 12/09/2021 | W | 118 | Colgate (23 - 11) | 71 | 68 | ||
| 12/12/2021 | L | 94 | Monmouth (21 - 13) | 52 | 56 | ||
| 12/18/2021 | W | at | 143 | St. John's (17 - 15) | 59 | 57 | |
| 12/21/2021 | W | 137 | Jacksonville (21 - 10) | 64 | 55 | ||
| 12/28/2021 | L | 61 | Notre Dame (22 - 10) | 67 | 68 | ||
| 01/05/2022 | L | at | 210 | Louisville (13 - 19) | 72 | 75 | |
| 01/08/2022 | W | 251 | Boston College (13 - 20) | 69 | 67 | ||
| 01/11/2022 | L | at | 164 | Syracuse (16 - 17) | 61 | 77 | |
| 01/15/2022 | W | 210 | Louisville (13 - 19) | 65 | 53 | ||
| 01/19/2022 | L | 100 | Virginia (19 - 13) | 61 | 66 | ||
| 01/22/2022 | L | at | 156 | Clemson (17 - 16) | 48 | 75 | |
| 01/25/2022 | W | 164 | Syracuse (16 - 17) | 64 | 53 | ||
| 01/30/2022 | L | at | 251 | Boston College (13 - 20) | 56 | 69 | |
| 02/02/2022 | L | at | 66 | Wake Forest (23 - 9) | 75 | 91 | |
| 02/05/2022 | L | 68 | Virginia Tech (23 - 12) | 71 | 76 | ||
| 02/07/2022 | L | at | 68 | Virginia Tech (23 - 12) | 47 | 74 | |
| 02/09/2022 | W | at | 133 | Florida St. (17 - 14) | 56 | 51 | |
| 02/12/2022 | W | 249 | N.C. State (11 - 21) | 71 | 69 | ||
| 02/16/2022 | W | at | 37 | North Carolina (24 - 9) | 76 | 67 | |
| 02/19/2022 | L | 266 | Georgia Tech (12 - 20) | 62 | 68 | ||
| 02/22/2022 | L | 46 | Miami FL (23 - 10) | 64 | 85 | ||
| 03/01/2022 | L | 8 | Duke (28 - 6) | 56 | 86 | ||
| 03/05/2022 | L | at | 61 | Notre Dame (22 - 10) | 54 | 78 | |
| 03/08/2022 | L | 251 | Boston College (13 - 20) | 46 | 66 | Brooklyn, NY |