| Team: | Detroit Mercy | Rating: | -1.4286 | Average Socre: | 70.4483 |
| Conference: | Horizon | ||||
| Wins: | 14 | Losses: | 15 | Div 1 Games: | 28 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | L | at | 36 | Wyoming (25 - 8) | 47 | 85 | |
| 11/13/2021 | L | at | 42 | Toledo (26 - 7) | 73 | 81 | |
| 11/17/2021 | L | at | 108 | Mississippi St. (18 - 15) | 64 | 77 | |
| 11/20/2021 | L | at | 210 | Louisville (13 - 19) | 67 | 73 | |
| 11/27/2021 | L | at | 89 | Hofstra (21 - 11) | 84 | 98 | |
| 11/30/2021 | L | at | 281 | Northeastern (9 - 22) | 56 | 66 | |
| 12/02/2021 | W | at | 358 | IUPUI (3 - 26) | 69 | 45 | |
| 12/05/2021 | W | at | 247 | Illinois Chicago (14 - 16) | 64 | 56 | |
| 12/09/2021 | L | at | 73 | Kent St. (23 - 10) | 52 | 69 | |
| 12/11/2021 | W | 316 | Western Michigan (8 - 23) | 83 | 64 | ||
| 12/19/2021 | W | 310 | Central Michigan (7 - 23) | 89 | 75 | ||
| 01/07/2022 | W | 311 | Milwaukee (10 - 22) | 85 | 60 | ||
| 01/13/2022 | L | at | 129 | Purdue Fort Wayne (21 - 11) | 60 | 62 | |
| 01/15/2022 | L | at | 111 | Cleveland St. (20 - 10) | 70 | 72 | |
| 01/20/2022 | L | at | 351 | Green Bay (5 - 25) | 63 | 70 | |
| 01/22/2022 | W | at | 311 | Milwaukee (10 - 22) | 71 | 58 | |
| 01/27/2022 | W | 247 | Illinois Chicago (14 - 16) | 80 | 67 | ||
| 01/31/2022 | W | Michigan Dearborn ( - ) | 96 | 51 | |||
| 02/04/2022 | L | at | 139 | Wright St. (21 - 13) | 59 | 90 | |
| 02/05/2022 | W | at | 148 | Northern Kentucky (20 - 12) | 74 | 68 | |
| 02/09/2022 | W | at | 329 | Robert Morris (8 - 24) | 79 | 62 | |
| 02/11/2022 | L | at | 214 | Youngstown St. (18 - 14) | 69 | 82 | |
| 02/13/2022 | L | at | 125 | Oakland (20 - 12) | 59 | 75 | |
| 02/18/2022 | W | 148 | Northern Kentucky (20 - 12) | 60 | 52 | ||
| 02/20/2022 | W | 139 | Wright St. (21 - 13) | 80 | 75 | ||
| 02/24/2022 | W | 111 | Cleveland St. (20 - 10) | 74 | 67 | ||
| 02/26/2022 | L | 129 | Purdue Fort Wayne (21 - 11) | 78 | 81 | ||
| 03/01/2022 | W | 351 | Green Bay (5 - 25) | 79 | 62 | ||
| 03/03/2022 | L | at | 148 | Northern Kentucky (20 - 12) | 59 | 77 |