| Team: | DePaul | Rating: | 0.8387 | Average Socre: | 73.2903 |
| Conference: | Big East | ||||
| Wins: | 15 | Losses: | 16 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | W | 296 | Coppin St. (9 - 23) | 97 | 72 | ||
| 11/13/2021 | W | 310 | Central Michigan (7 - 23) | 99 | 66 | ||
| 11/18/2021 | W | 109 | Rutgers (18 - 13) | 73 | 70 | ||
| 11/20/2021 | W | 217 | Western Illinois (16 - 15) | 84 | 80 | ||
| 11/26/2021 | W | 148 | Northern Kentucky (20 - 12) | 77 | 68 | ||
| 11/28/2021 | W | 300 | Eastern Michigan (10 - 21) | 101 | 63 | ||
| 12/04/2021 | L | 34 | Loyola Chicago (25 - 7) | 64 | 68 | ||
| 12/07/2021 | W | 334 | Duquesne (6 - 24) | 87 | 67 | ||
| 12/10/2021 | W | at | 210 | Louisville (13 - 19) | 62 | 55 | |
| 12/14/2021 | W | at | 247 | Illinois Chicago (14 - 16) | 72 | 66 | |
| 12/29/2021 | L | at | 205 | Butler (14 - 19) | 59 | 63 | |
| 01/01/2022 | L | 10 | Providence (25 - 5) | 53 | 70 | ||
| 01/05/2022 | L | at | 143 | St. John's (17 - 15) | 84 | 89 | |
| 01/08/2022 | L | 14 | Villanova (26 - 7) | 64 | 79 | ||
| 01/11/2022 | L | at | 78 | Marquette (19 - 12) | 76 | 87 | |
| 01/13/2022 | W | 59 | Seton Hall (21 - 10) | 96 | 92 | ||
| 01/19/2022 | L | 83 | Xavier (18 - 13) | 67 | 68 | ||
| 01/22/2022 | L | at | 51 | Creighton (22 - 11) | 47 | 60 | |
| 01/25/2022 | L | at | 14 | Villanova (26 - 7) | 43 | 67 | |
| 01/29/2022 | L | 40 | Connecticut (23 - 9) | 50 | 57 | ||
| 02/05/2022 | W | at | 83 | Xavier (18 - 13) | 69 | 65 | |
| 02/09/2022 | W | 303 | Georgetown (6 - 25) | 82 | 74 | ||
| 02/12/2022 | L | at | 10 | Providence (25 - 5) | 73 | 76 | |
| 02/15/2022 | L | 205 | Butler (14 - 19) | 71 | 73 | ||
| 02/17/2022 | L | 51 | Creighton (22 - 11) | 59 | 71 | ||
| 02/19/2022 | L | at | 59 | Seton Hall (21 - 10) | 64 | 66 | |
| 02/24/2022 | W | at | 303 | Georgetown (6 - 25) | 68 | 65 | |
| 02/27/2022 | W | 143 | St. John's (17 - 15) | 99 | 94 | ||
| 03/02/2022 | W | 78 | Marquette (19 - 12) | 91 | 80 | ||
| 03/05/2022 | L | at | 40 | Connecticut (23 - 9) | 68 | 75 | |
| 03/09/2022 | L | at | 143 | St. John's (17 - 15) | 73 | 92 | New York, NY |