| Team: | Notre Dame | Rating: | 6.5484 | Average Socre: | 72.5 |
| Conference: | ACC | ||||
| Wins: | 22 | Losses: | 10 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/13/2021 | W | 309 | Cal St. Northridge (7 - 23) | 68 | 52 | ||
| 11/16/2021 | W | 239 | High Point (14 - 18) | 70 | 61 | ||
| 11/22/2021 | L | 11 | Saint Mary's (25 - 7) | 59 | 62 | Las Vegas, NV | |
| 11/23/2021 | W | Chaminade ( - ) | 90 | 64 | Las Vegas, NV | ||
| 11/24/2021 | L | 63 | Texas A&M (23 - 12) | 67 | 73 | Las Vegas, NV | |
| 11/29/2021 | L | at | 38 | Illinois (22 - 9) | 72 | 82 | |
| 12/03/2021 | L | at | 251 | Boston College (13 - 20) | 57 | 73 | |
| 12/11/2021 | W | 13 | Kentucky (26 - 7) | 66 | 62 | ||
| 12/18/2021 | L | at | 92 | Indiana (20 - 13) | 56 | 64 | Indianapolis, IN |
| 12/20/2021 | W | 316 | Western Michigan (8 - 23) | 85 | 52 | ||
| 12/22/2021 | W | 167 | Texas A&M Corpus Chris (23 - 11) | 83 | 73 | ||
| 12/28/2021 | W | at | 245 | Pittsburgh (11 - 21) | 68 | 67 | |
| 01/05/2022 | W | 37 | North Carolina (24 - 9) | 78 | 73 | ||
| 01/08/2022 | W | at | 266 | Georgia Tech (12 - 20) | 72 | 68 | |
| 01/12/2022 | W | 156 | Clemson (17 - 16) | 72 | 56 | ||
| 01/15/2022 | L | at | 68 | Virginia Tech (23 - 12) | 73 | 79 | |
| 01/17/2022 | W | at | 225 | Howard (16 - 13) | 71 | 68 | |
| 01/22/2022 | W | at | 210 | Louisville (13 - 19) | 82 | 70 | |
| 01/26/2022 | W | 249 | N.C. State (11 - 21) | 73 | 65 | ||
| 01/29/2022 | W | 100 | Virginia (19 - 13) | 69 | 65 | ||
| 01/31/2022 | L | 8 | Duke (28 - 6) | 43 | 57 | ||
| 02/02/2022 | W | at | 46 | Miami FL (23 - 10) | 68 | 64 | |
| 02/05/2022 | W | at | 249 | N.C. State (11 - 21) | 69 | 57 | |
| 02/09/2022 | W | 210 | Louisville (13 - 19) | 63 | 57 | ||
| 02/12/2022 | W | at | 156 | Clemson (17 - 16) | 76 | 61 | |
| 02/16/2022 | W | 251 | Boston College (13 - 20) | 99 | 95 | ||
| 02/19/2022 | L | at | 66 | Wake Forest (23 - 9) | 74 | 79 | |
| 02/23/2022 | W | 164 | Syracuse (16 - 17) | 79 | 69 | ||
| 02/26/2022 | W | 266 | Georgia Tech (12 - 20) | 90 | 56 | ||
| 03/02/2022 | L | at | 133 | Florida St. (17 - 14) | 70 | 74 | |
| 03/05/2022 | W | 245 | Pittsburgh (11 - 21) | 78 | 54 | ||
| 03/10/2022 | L | 68 | Virginia Tech (23 - 12) | 80 | 87 | Brooklyn, NY |