| Team: | Southern | Rating: | -1.2759 | Average Socre: | 71.9032 |
| Conference: | Southwestern | ||||
| Wins: | 17 | Losses: | 14 | Div 1 Games: | 29 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 210 | Louisville (13 - 19) | 60 | 72 | |
| 11/13/2021 | W | at | 159 | Tulane (14 - 15) | 73 | 70 | |
| 11/16/2021 | L | at | 188 | Rice (16 - 16) | 63 | 81 | |
| 11/19/2021 | L | at | 150 | South Dakota (19 - 12) | 68 | 71 | |
| 11/21/2021 | L | at | 265 | Nebraska (10 - 22) | 59 | 82 | |
| 11/23/2021 | W | Ecclesia ( - ) | 109 | 53 | |||
| 11/28/2021 | W | at | 277 | Tennessee St. (14 - 18) | 82 | 80 | |
| 12/04/2021 | L | at | 74 | Akron (24 - 9) | 62 | 79 | |
| 12/07/2021 | L | at | 13 | Kentucky (26 - 7) | 64 | 76 | |
| 12/09/2021 | W | Lindsey Wilson ( - ) | 86 | 68 | |||
| 12/11/2021 | W | 174 | Southeastern Louisiana (19 - 14) | 72 | 66 | ||
| 12/19/2021 | W | at | 73 | Kent St. (23 - 10) | 78 | 76 | |
| 12/21/2021 | L | at | 52 | Dayton (23 - 10) | 60 | 69 | |
| 01/03/2022 | W | 187 | Texas Southern (18 - 12) | 63 | 50 | ||
| 01/08/2022 | W | at | 278 | Florida A&M (13 - 17) | 80 | 66 | |
| 01/10/2022 | W | at | 337 | Bethune Cookman (9 - 21) | 69 | 59 | |
| 01/15/2022 | L | at | 294 | Grambling St. (12 - 20) | 77 | 83 | |
| 01/22/2022 | W | 347 | Arkansas Pine Bluff (7 - 24) | 99 | 51 | ||
| 01/24/2022 | W | 356 | Mississippi Valley St. (2 - 26) | 100 | 72 | ||
| 01/29/2022 | L | at | 213 | Alcorn St. (17 - 16) | 64 | 68 | |
| 01/31/2022 | W | at | 299 | Jackson St. (11 - 19) | 75 | 64 | |
| 02/05/2022 | W | 292 | Alabama A&M (12 - 18) | 73 | 64 | ||
| 02/07/2022 | W | 328 | Alabama St. (10 - 21) | 72 | 58 | ||
| 02/12/2022 | L | at | 305 | Prairie View A&M (8 - 19) | 77 | 84 | |
| 02/14/2022 | W | at | 187 | Texas Southern (18 - 12) | 70 | 58 | |
| 02/19/2022 | L | 294 | Grambling St. (12 - 20) | 57 | 61 | ||
| 02/26/2022 | L | 337 | Bethune Cookman (9 - 21) | 84 | 87 | ||
| 02/28/2022 | W | 278 | Florida A&M (13 - 17) | 58 | 49 | ||
| 03/03/2022 | L | at | 328 | Alabama St. (10 - 21) | 67 | 77 | |
| 03/05/2022 | W | at | 292 | Alabama A&M (12 - 18) | 50 | 49 | |
| 03/10/2022 | L | 294 | Grambling St. (12 - 20) | 58 | 60 | Birmingham, AL |