| Team: | Duke | Rating: | 12.2059 | Average Socre: | 80.1765 |
| Conference: | ACC | ||||
| Wins: | 28 | Losses: | 6 | Div 1 Games: | 34 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 13 | Kentucky (26 - 7) | 79 | 71 | New York, NY | |
| 11/12/2021 | W | 235 | Army (15 - 16) | 82 | 56 | ||
| 11/13/2021 | W | 198 | Campbell (16 - 13) | 67 | 56 | ||
| 11/16/2021 | W | 170 | Gardner Webb (18 - 13) | 92 | 52 | ||
| 11/19/2021 | W | 304 | Lafayette (10 - 20) | 88 | 55 | ||
| 11/22/2021 | W | 244 | The Citadel (13 - 18) | 107 | 81 | ||
| 11/26/2021 | W | 1 | Gonzaga (26 - 3) | 84 | 81 | Las Vegas, NV | |
| 11/30/2021 | L | at | 76 | Ohio St. (19 - 11) | 66 | 71 | |
| 12/14/2021 | W | 268 | South Carolina St. (15 - 16) | 103 | 62 | ||
| 12/16/2021 | W | 122 | Appalachian St. (19 - 14) | 92 | 67 | ||
| 12/18/2021 | W | 286 | Elon (10 - 22) | 87 | 56 | ||
| 12/22/2021 | W | 68 | Virginia Tech (23 - 12) | 76 | 65 | ||
| 01/04/2022 | W | 266 | Georgia Tech (12 - 20) | 69 | 57 | ||
| 01/08/2022 | L | 46 | Miami FL (23 - 10) | 74 | 76 | ||
| 01/12/2022 | W | at | 66 | Wake Forest (23 - 9) | 76 | 64 | |
| 01/15/2022 | W | 249 | N.C. State (11 - 21) | 88 | 73 | ||
| 01/18/2022 | L | at | 133 | Florida St. (17 - 14) | 78 | 79 | |
| 01/22/2022 | W | 164 | Syracuse (16 - 17) | 79 | 59 | ||
| 01/25/2022 | W | 156 | Clemson (17 - 16) | 71 | 69 | ||
| 01/29/2022 | W | at | 210 | Louisville (13 - 19) | 74 | 65 | |
| 01/31/2022 | W | at | 61 | Notre Dame (22 - 10) | 57 | 43 | |
| 02/05/2022 | W | at | 37 | North Carolina (24 - 9) | 87 | 67 | |
| 02/07/2022 | L | 100 | Virginia (19 - 13) | 68 | 69 | ||
| 02/10/2022 | W | at | 156 | Clemson (17 - 16) | 82 | 64 | |
| 02/12/2022 | W | at | 251 | Boston College (13 - 20) | 72 | 61 | |
| 02/15/2022 | W | 66 | Wake Forest (23 - 9) | 76 | 74 | ||
| 02/19/2022 | W | 133 | Florida St. (17 - 14) | 88 | 70 | ||
| 02/23/2022 | W | at | 100 | Virginia (19 - 13) | 65 | 61 | |
| 02/26/2022 | W | at | 164 | Syracuse (16 - 17) | 97 | 72 | |
| 03/01/2022 | W | at | 245 | Pittsburgh (11 - 21) | 86 | 56 | |
| 03/05/2022 | L | 37 | North Carolina (24 - 9) | 81 | 94 | ||
| 03/10/2022 | W | 164 | Syracuse (16 - 17) | 88 | 79 | Brooklyn, NY | |
| 03/11/2022 | W | 46 | Miami FL (23 - 10) | 80 | 76 | Brooklyn, NY | |
| 03/12/2022 | L | 68 | Virginia Tech (23 - 12) | 67 | 82 | Brooklyn, NY |