| Team: | Western Kentucky | Rating: | 2.6 | Average Socre: | 75.4375 |
| Conference: | Conference USA | ||||
| Wins: | 19 | Losses: | 13 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 328 | Alabama St. (10 - 21) | 79 | 74 | ||
| 11/12/2021 | L | at | 179 | Minnesota (13 - 17) | 69 | 73 | Asheville, NC |
| 11/14/2021 | L | at | 97 | South Carolina (18 - 13) | 64 | 75 | Asheville, NC |
| 11/19/2021 | L | at | 45 | Memphis (21 - 10) | 62 | 74 | |
| 11/24/2021 | W | 292 | Alabama A&M (12 - 18) | 88 | 62 | ||
| 11/27/2021 | W | 332 | Tennessee Martin (8 - 22) | 81 | 66 | ||
| 11/30/2021 | W | Rhodes ( - ) | 105 | 35 | |||
| 12/04/2021 | W | 298 | Eastern Kentucky (13 - 18) | 85 | 80 | ||
| 12/08/2021 | L | 114 | Buffalo (19 - 11) | 67 | 77 | ||
| 12/11/2021 | W | at | 209 | Mississippi (13 - 19) | 71 | 48 | Atlanta, GA |
| 12/14/2021 | W | Centre ( - ) | 90 | 52 | |||
| 12/18/2021 | W | 210 | Louisville (13 - 19) | 82 | 72 | ||
| 12/22/2021 | L | at | 13 | Kentucky (26 - 7) | 60 | 95 | |
| 01/01/2022 | L | at | 67 | Louisiana Tech (24 - 10) | 73 | 74 | |
| 01/08/2022 | W | 250 | FIU (15 - 17) | 84 | 71 | ||
| 01/13/2022 | W | 188 | Rice (16 - 16) | 80 | 66 | ||
| 01/15/2022 | L | 19 | North Texas (24 - 6) | 60 | 65 | ||
| 01/20/2022 | L | at | 168 | Florida Atlantic (19 - 14) | 69 | 78 | |
| 01/22/2022 | L | at | 250 | FIU (15 - 17) | 83 | 86 | |
| 01/27/2022 | L | 24 | UAB (27 - 7) | 65 | 68 | ||
| 01/29/2022 | L | 62 | Middle Tennessee (23 - 10) | 85 | 93 | ||
| 02/03/2022 | W | at | 138 | Charlotte (17 - 14) | 78 | 59 | |
| 02/05/2022 | W | at | 221 | Old Dominion (13 - 19) | 77 | 60 | |
| 02/10/2022 | W | 168 | Florida Atlantic (19 - 14) | 76 | 69 | ||
| 02/12/2022 | W | at | 323 | UTSA (10 - 22) | 71 | 65 | |
| 02/14/2022 | W | at | 340 | Southern Miss (7 - 26) | 87 | 77 | |
| 02/17/2022 | W | 138 | Charlotte (17 - 14) | 77 | 67 | ||
| 02/19/2022 | W | 221 | Old Dominion (13 - 19) | 73 | 64 | ||
| 02/26/2022 | L | at | 62 | Middle Tennessee (23 - 10) | 52 | 69 | |
| 03/02/2022 | W | at | 261 | Marshall (12 - 21) | 86 | 72 | |
| 03/05/2022 | W | 261 | Marshall (12 - 21) | 78 | 69 | ||
| 03/10/2022 | L | 67 | Louisiana Tech (24 - 10) | 57 | 59 | Frisco, TX |