| Team: | Florida St. | Rating: | 2.871 | Average Socre: | 71 |
| Conference: | ACC | ||||
| Wins: | 17 | Losses: | 14 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | W | 220 | Penn (12 - 16) | 105 | 70 | ||
| 11/14/2021 | L | at | 106 | Florida (19 - 13) | 55 | 71 | |
| 11/17/2021 | W | 159 | Tulane (14 - 15) | 59 | 54 | ||
| 11/21/2021 | W | at | 226 | Loyola Marymount (11 - 18) | 73 | 45 | Jacksonville, FL |
| 11/22/2021 | W | at | 238 | Missouri (12 - 21) | 81 | 58 | Jacksonville, FL |
| 11/24/2021 | W | 158 | Boston University (21 - 12) | 81 | 80 | ||
| 11/30/2021 | L | at | 15 | Purdue (27 - 7) | 65 | 93 | |
| 12/04/2021 | L | 164 | Syracuse (16 - 17) | 60 | 63 | ||
| 12/12/2021 | L | at | 97 | South Carolina (18 - 13) | 65 | 66 | Rock Hill, SC |
| 12/15/2021 | W | 263 | Lipscomb (14 - 19) | 97 | 60 | ||
| 01/01/2022 | W | at | 249 | N.C. State (11 - 21) | 83 | 81 | |
| 01/04/2022 | L | at | 66 | Wake Forest (23 - 9) | 54 | 76 | |
| 01/08/2022 | W | 210 | Louisville (13 - 19) | 79 | 70 | ||
| 01/11/2022 | W | 46 | Miami FL (23 - 10) | 65 | 64 | ||
| 01/15/2022 | W | at | 164 | Syracuse (16 - 17) | 76 | 71 | |
| 01/18/2022 | W | 8 | Duke (28 - 6) | 79 | 78 | ||
| 01/20/2022 | W | 285 | North Florida (11 - 20) | 86 | 73 | ||
| 01/22/2022 | W | at | 46 | Miami FL (23 - 10) | 61 | 60 | |
| 01/26/2022 | L | at | 266 | Georgia Tech (12 - 20) | 61 | 75 | |
| 01/29/2022 | L | 68 | Virginia Tech (23 - 12) | 72 | 85 | ||
| 02/02/2022 | L | at | 156 | Clemson (17 - 16) | 69 | 75 | |
| 02/05/2022 | L | 66 | Wake Forest (23 - 9) | 60 | 68 | ||
| 02/09/2022 | L | 245 | Pittsburgh (11 - 21) | 51 | 56 | ||
| 02/12/2022 | L | at | 37 | North Carolina (24 - 9) | 74 | 94 | |
| 02/15/2022 | W | 156 | Clemson (17 - 16) | 81 | 80 | ||
| 02/19/2022 | L | at | 8 | Duke (28 - 6) | 70 | 88 | |
| 02/21/2022 | L | at | 251 | Boston College (13 - 20) | 55 | 71 | |
| 02/26/2022 | W | at | 100 | Virginia (19 - 13) | 64 | 63 | |
| 03/02/2022 | W | 61 | Notre Dame (22 - 10) | 74 | 70 | ||
| 03/05/2022 | W | 249 | N.C. State (11 - 21) | 89 | 76 | ||
| 03/09/2022 | L | 164 | Syracuse (16 - 17) | 57 | 96 | Brooklyn, NY |