| Team: | Clemson | Rating: | 2.0303 | Average Socre: | 71.7273 |
| Conference: | ACC | ||||
| Wins: | 17 | Losses: | 16 | Div 1 Games: | 33 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 290 | Presbyterian (12 - 20) | 64 | 53 | ||
| 11/12/2021 | W | 142 | Wofford (19 - 13) | 76 | 68 | ||
| 11/15/2021 | W | 102 | Bryant (22 - 9) | 93 | 70 | ||
| 11/18/2021 | W | at | 124 | Temple (17 - 12) | 75 | 48 | Charleston, SC |
| 11/19/2021 | L | 48 | St. Bonaventure (20 - 9) | 65 | 68 | Charleston, SC | |
| 11/21/2021 | L | at | 130 | West Virginia (16 - 17) | 59 | 66 | Charleston, SC |
| 11/26/2021 | W | 353 | Charleston Southern (6 - 25) | 91 | 59 | ||
| 11/30/2021 | L | at | 109 | Rutgers (18 - 13) | 64 | 74 | |
| 12/04/2021 | L | at | 46 | Miami FL (23 - 10) | 75 | 80 | |
| 12/11/2021 | W | at | 70 | Drake (24 - 10) | 90 | 80 | Atlanta, GA |
| 12/14/2021 | W | 276 | Miami OH (14 - 18) | 89 | 76 | ||
| 12/18/2021 | W | 97 | South Carolina (18 - 13) | 70 | 56 | ||
| 12/22/2021 | W | at | 100 | Virginia (19 - 13) | 67 | 50 | |
| 01/04/2022 | L | 100 | Virginia (19 - 13) | 65 | 75 | ||
| 01/08/2022 | W | at | 249 | N.C. State (11 - 21) | 70 | 65 | |
| 01/12/2022 | L | at | 61 | Notre Dame (22 - 10) | 56 | 72 | |
| 01/15/2022 | L | 251 | Boston College (13 - 20) | 68 | 70 | ||
| 01/18/2022 | L | at | 164 | Syracuse (16 - 17) | 78 | 91 | |
| 01/22/2022 | W | 245 | Pittsburgh (11 - 21) | 75 | 48 | ||
| 01/25/2022 | L | at | 8 | Duke (28 - 6) | 69 | 71 | |
| 02/02/2022 | W | 133 | Florida St. (17 - 14) | 75 | 69 | ||
| 02/05/2022 | L | at | 266 | Georgia Tech (12 - 20) | 64 | 69 | |
| 02/08/2022 | L | 37 | North Carolina (24 - 9) | 77 | 79 | ||
| 02/10/2022 | L | 8 | Duke (28 - 6) | 64 | 82 | ||
| 02/12/2022 | L | 61 | Notre Dame (22 - 10) | 61 | 76 | ||
| 02/15/2022 | L | at | 133 | Florida St. (17 - 14) | 80 | 81 | |
| 02/19/2022 | L | at | 210 | Louisville (13 - 19) | 61 | 70 | |
| 02/23/2022 | W | 66 | Wake Forest (23 - 9) | 80 | 69 | ||
| 02/26/2022 | W | at | 251 | Boston College (13 - 20) | 70 | 60 | |
| 03/02/2022 | W | 266 | Georgia Tech (12 - 20) | 68 | 65 | ||
| 03/05/2022 | W | 68 | Virginia Tech (23 - 12) | 63 | 59 | ||
| 03/08/2022 | W | 249 | N.C. State (11 - 21) | 70 | 64 | Brooklyn, NY | |
| 03/09/2022 | L | at | 68 | Virginia Tech (23 - 12) | 75 | 76 | Brooklyn, NY |