| Team: | William & Mary | Rating: | -10.3548 | Average Socre: | 63.875 |
| Conference: | Colonial | ||||
| Wins: | 5 | Losses: | 27 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | L | at | 66 | Wake Forest (23 - 9) | 59 | 77 | |
| 11/12/2021 | L | 318 | American (10 - 22) | 62 | 74 | ||
| 11/16/2021 | L | at | 86 | Norfolk St. (24 - 6) | 74 | 91 | |
| 11/20/2021 | L | 132 | Georgia St. (18 - 10) | 59 | 77 | High Point, NC | |
| 11/21/2021 | L | 225 | Howard (16 - 13) | 76 | 82 | High Point, NC | |
| 11/24/2021 | L | at | 287 | Radford (11 - 18) | 54 | 67 | |
| 11/27/2021 | W | Mary Baldwin ( - ) | 87 | 50 | |||
| 12/01/2021 | L | at | 121 | Navy (21 - 11) | 56 | 75 | |
| 12/04/2021 | L | at | 28 | Davidson (27 - 6) | 46 | 70 | |
| 12/07/2021 | L | 221 | Old Dominion (13 - 19) | 59 | 74 | ||
| 12/09/2021 | L | 306 | Hampton (9 - 19) | 53 | 54 | ||
| 12/12/2021 | L | 222 | Fairfield (15 - 18) | 47 | 70 | ||
| 12/22/2021 | L | at | 243 | Valparaiso (14 - 18) | 66 | 88 | |
| 12/29/2021 | W | 89 | Hofstra (21 - 11) | 63 | 62 | ||
| 12/31/2021 | W | 281 | Northeastern (9 - 22) | 71 | 70 | ||
| 01/15/2022 | L | 182 | James Madison (15 - 14) | 91 | 95 | ||
| 01/17/2022 | L | 47 | Towson (25 - 8) | 69 | 91 | ||
| 01/20/2022 | L | at | 91 | Delaware (22 - 12) | 74 | 84 | |
| 01/22/2022 | W | at | 185 | Drexel (15 - 14) | 83 | 75 | |
| 01/25/2022 | L | at | 160 | Charleston (17 - 15) | 73 | 74 | |
| 01/27/2022 | L | at | 286 | Elon (10 - 22) | 54 | 61 | |
| 01/29/2022 | W | 286 | Elon (10 - 22) | 65 | 61 | ||
| 02/03/2022 | L | 160 | Charleston (17 - 15) | 61 | 84 | ||
| 02/05/2022 | L | 85 | UNC Wilmington (23 - 9) | 70 | 92 | ||
| 02/10/2022 | L | at | 47 | Towson (25 - 8) | 60 | 75 | |
| 02/12/2022 | L | at | 182 | James Madison (15 - 14) | 55 | 69 | |
| 02/14/2022 | L | at | 85 | UNC Wilmington (23 - 9) | 73 | 80 | |
| 02/17/2022 | L | 185 | Drexel (15 - 14) | 57 | 72 | ||
| 02/19/2022 | L | 91 | Delaware (22 - 12) | 69 | 73 | ||
| 02/24/2022 | L | at | 281 | Northeastern (9 - 22) | 28 | 62 | |
| 02/26/2022 | L | at | 89 | Hofstra (21 - 11) | 67 | 83 | |
| 03/05/2022 | L | 281 | Northeastern (9 - 22) | 63 | 68 | Washington, DC |