| Team: | USC Upstate | Rating: | -1.7143 | Average Socre: | 70.9333 |
| Conference: | Big South | ||||
| Wins: | 14 | Losses: | 16 | Div 1 Games: | 28 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 97 | South Carolina (18 - 13) | 60 | 78 | |
| 11/12/2021 | L | at | 138 | Charlotte (17 - 14) | 64 | 76 | |
| 11/15/2021 | W | St. Andrews Pres. ( - ) | 96 | 43 | |||
| 11/18/2021 | L | at | 184 | East Tennessee St. (15 - 17) | 43 | 56 | |
| 11/23/2021 | W | at | 268 | South Carolina St. (15 - 16) | 82 | 78 | |
| 11/27/2021 | L | 77 | Furman (22 - 12) | 77 | 87 | ||
| 12/01/2021 | L | 241 | North Carolina Central (16 - 15) | 65 | 67 | ||
| 12/04/2021 | L | 273 | Western Carolina (11 - 21) | 73 | 78 | ||
| 12/11/2021 | L | at | 66 | Wake Forest (23 - 9) | 53 | 79 | |
| 12/14/2021 | L | at | 6 | Tennessee (26 - 7) | 52 | 96 | |
| 12/18/2021 | W | Converse ( - ) | 78 | 38 | |||
| 12/21/2021 | L | at | 65 | Ohio (24 - 9) | 70 | 85 | |
| 01/06/2022 | L | 287 | Radford (11 - 18) | 77 | 82 | ||
| 01/08/2022 | W | at | 290 | Presbyterian (12 - 20) | 82 | 72 | |
| 01/12/2022 | W | 239 | High Point (14 - 18) | 66 | 65 | ||
| 01/15/2022 | W | at | 208 | UNC Asheville (16 - 14) | 76 | 73 | |
| 01/19/2022 | W | at | 170 | Gardner Webb (18 - 13) | 74 | 61 | |
| 01/22/2022 | W | 353 | Charleston Southern (6 - 25) | 70 | 57 | ||
| 01/26/2022 | L | 84 | Winthrop (23 - 9) | 91 | 95 | ||
| 01/29/2022 | W | at | 289 | North Carolina A&T (12 - 20) | 84 | 64 | |
| 02/02/2022 | W | at | 306 | Hampton (9 - 19) | 85 | 78 | |
| 02/05/2022 | L | 198 | Campbell (16 - 13) | 71 | 80 | ||
| 02/10/2022 | L | at | 56 | Longwood (26 - 6) | 72 | 85 | |
| 02/12/2022 | L | 208 | UNC Asheville (16 - 14) | 56 | 83 | ||
| 02/16/2022 | W | 290 | Presbyterian (12 - 20) | 60 | 55 | ||
| 02/19/2022 | W | at | 353 | Charleston Southern (6 - 25) | 78 | 73 | |
| 02/24/2022 | L | at | 84 | Winthrop (23 - 9) | 59 | 89 | |
| 02/26/2022 | W | 170 | Gardner Webb (18 - 13) | 72 | 70 | ||
| 03/04/2022 | W | 353 | Charleston Southern (6 - 25) | 72 | 62 | Charlotte, NC | |
| 03/05/2022 | L | at | 56 | Longwood (26 - 6) | 70 | 79 | Charlotte, NC |