| Team: | South Carolina St. | Rating: | -4.0714 | Average Socre: | 71.8387 |
| Conference: | Mid Eastern | ||||
| Wins: | 15 | Losses: | 16 | Div 1 Games: | 28 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 186 | East Carolina (15 - 15) | 62 | 70 | |
| 11/11/2021 | L | at | 160 | Charleston (17 - 15) | 74 | 106 | |
| 11/12/2021 | L | at | 242 | Loyola MD (14 - 16) | 65 | 75 | Charleston, SC |
| 11/13/2021 | L | 263 | Lipscomb (14 - 19) | 81 | 93 | Charleston, SC | |
| 11/16/2021 | L | at | 320 | Georgia (6 - 26) | 60 | 76 | |
| 11/18/2021 | W | St. Andrews Pres. ( - ) | 67 | 53 | |||
| 11/23/2021 | L | 218 | USC Upstate (14 - 16) | 78 | 82 | ||
| 11/28/2021 | L | 244 | The Citadel (13 - 18) | 79 | 91 | ||
| 12/03/2021 | W | at | 295 | South Florida (8 - 23) | 65 | 64 | |
| 12/10/2021 | W | 239 | High Point (14 - 18) | 67 | 66 | Rock Hill, SC | |
| 12/14/2021 | L | at | 8 | Duke (28 - 6) | 62 | 103 | |
| 12/16/2021 | W | Carver ( - ) | 105 | 46 | |||
| 12/18/2021 | W | 277 | Tennessee St. (14 - 18) | 90 | 88 | ||
| 12/20/2021 | W | at | 244 | The Citadel (13 - 18) | 74 | 57 | |
| 12/21/2021 | W | at | 353 | Charleston Southern (6 - 25) | 75 | 65 | Charleston, SC |
| 01/08/2022 | L | 296 | Coppin St. (9 - 23) | 65 | 74 | ||
| 01/10/2022 | L | 256 | Morgan St. (13 - 14) | 81 | 88 | ||
| 01/18/2022 | W | Morris ( - ) | 102 | 67 | |||
| 01/22/2022 | W | at | 280 | Maryland Eastern Shore (11 - 15) | 69 | 60 | |
| 01/24/2022 | W | at | 355 | Delaware St. (2 - 26) | 64 | 62 | |
| 01/29/2022 | L | 86 | Norfolk St. (24 - 6) | 69 | 87 | ||
| 01/31/2022 | W | 225 | Howard (16 - 13) | 58 | 55 | ||
| 02/07/2022 | W | 241 | North Carolina Central (16 - 15) | 74 | 68 | ||
| 02/12/2022 | W | at | 296 | Coppin St. (9 - 23) | 66 | 58 | |
| 02/14/2022 | L | at | 256 | Morgan St. (13 - 14) | 66 | 76 | |
| 02/19/2022 | W | 280 | Maryland Eastern Shore (11 - 15) | 70 | 63 | ||
| 02/21/2022 | W | 355 | Delaware St. (2 - 26) | 79 | 74 | ||
| 02/26/2022 | L | at | 86 | Norfolk St. (24 - 6) | 59 | 63 | |
| 02/28/2022 | L | at | 225 | Howard (16 - 13) | 62 | 72 | |
| 03/03/2022 | L | at | 241 | North Carolina Central (16 - 15) | 62 | 67 | |
| 03/10/2022 | L | at | 256 | Morgan St. (13 - 14) | 77 | 80 | Norfolk, VA |