| Team: | Ohio St. | Rating: | 6.0667 | Average Socre: | 73.8 |
| Conference: | Big Ten | ||||
| Wins: | 19 | Losses: | 11 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 74 | Akron (24 - 9) | 67 | 66 | ||
| 11/12/2021 | W | 211 | Niagara (14 - 16) | 84 | 74 | ||
| 11/15/2021 | W | 264 | Bowling Green (13 - 18) | 89 | 58 | ||
| 11/18/2021 | L | at | 83 | Xavier (18 - 13) | 65 | 71 | |
| 11/22/2021 | W | at | 59 | Seton Hall (21 - 10) | 79 | 76 | Fort Myers, FL |
| 11/24/2021 | L | at | 106 | Florida (19 - 13) | 68 | 71 | Fort Myers, FL |
| 11/30/2021 | W | 8 | Duke (28 - 6) | 71 | 66 | ||
| 12/05/2021 | W | at | 175 | Penn St. (14 - 17) | 76 | 64 | |
| 12/08/2021 | W | 47 | Towson (25 - 8) | 85 | 74 | ||
| 12/11/2021 | W | 18 | Wisconsin (24 - 7) | 73 | 55 | ||
| 01/02/2022 | W | at | 265 | Nebraska (10 - 22) | 87 | 79 | |
| 01/06/2022 | L | at | 92 | Indiana (20 - 13) | 51 | 67 | |
| 01/09/2022 | W | 193 | Northwestern (15 - 16) | 95 | 87 | ||
| 01/13/2022 | L | at | 18 | Wisconsin (24 - 7) | 68 | 78 | |
| 01/16/2022 | W | 175 | Penn St. (14 - 17) | 61 | 56 | ||
| 01/18/2022 | W | 358 | IUPUI (3 - 26) | 83 | 37 | ||
| 01/27/2022 | W | at | 179 | Minnesota (13 - 17) | 75 | 64 | |
| 01/30/2022 | L | at | 15 | Purdue (27 - 7) | 78 | 81 | |
| 02/06/2022 | W | 163 | Maryland (15 - 17) | 82 | 67 | ||
| 02/09/2022 | L | at | 109 | Rutgers (18 - 13) | 64 | 66 | |
| 02/12/2022 | W | at | 87 | Michigan (17 - 14) | 68 | 57 | |
| 02/15/2022 | W | 179 | Minnesota (13 - 17) | 70 | 45 | ||
| 02/19/2022 | L | 30 | Iowa (26 - 9) | 62 | 75 | ||
| 02/21/2022 | W | 92 | Indiana (20 - 13) | 80 | 69 | ||
| 02/24/2022 | W | at | 38 | Illinois (22 - 9) | 86 | 83 | |
| 02/27/2022 | L | at | 163 | Maryland (15 - 17) | 60 | 75 | |
| 03/01/2022 | L | 265 | Nebraska (10 - 22) | 70 | 78 | ||
| 03/03/2022 | W | 49 | Michigan St. (22 - 12) | 80 | 69 | ||
| 03/06/2022 | L | 87 | Michigan (17 - 14) | 69 | 75 | ||
| 03/10/2022 | L | 175 | Penn St. (14 - 17) | 68 | 71 | Indianapolis, IN |