| Team: | Appalachian St. | Rating: | 3.2667 | Average Socre: | 66.8788 |
| Conference: | Sun Belt | ||||
| Wins: | 19 | Losses: | 14 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 25 | Iona (25 - 7) | 53 | 65 | |
| 11/12/2021 | W | 184 | East Tennessee St. (15 - 17) | 69 | 67 | ||
| 11/15/2021 | W | William Peace ( - ) | 98 | 49 | |||
| 11/18/2021 | L | 138 | Charlotte (17 - 14) | 66 | 67 | ||
| 11/22/2021 | L | at | 91 | Delaware (22 - 12) | 68 | 75 | Estero, FL |
| 11/23/2021 | W | 74 | Akron (24 - 9) | 57 | 45 | Estero, FL | |
| 11/24/2021 | L | 29 | Vermont (28 - 5) | 63 | 65 | Estero, FL | |
| 11/29/2021 | W | 269 | Hartford (12 - 20) | 69 | 59 | ||
| 12/01/2021 | W | Boyce ( - ) | 90 | 29 | |||
| 12/10/2021 | L | at | 77 | Furman (22 - 12) | 65 | 73 | |
| 12/13/2021 | W | Erskine ( - ) | 69 | 44 | |||
| 12/16/2021 | L | at | 8 | Duke (28 - 6) | 67 | 92 | |
| 12/21/2021 | L | at | 37 | North Carolina (24 - 9) | 50 | 70 | |
| 12/30/2021 | L | 173 | Louisiana (16 - 15) | 55 | 71 | ||
| 01/01/2022 | W | 254 | Louisiana Monroe (13 - 18) | 77 | 69 | ||
| 01/06/2022 | W | at | 145 | South Alabama (19 - 11) | 72 | 64 | |
| 01/08/2022 | L | at | 120 | Troy (20 - 11) | 53 | 68 | |
| 01/13/2022 | W | 166 | Coastal Carolina (16 - 13) | 61 | 60 | ||
| 01/15/2022 | W | at | 166 | Coastal Carolina (16 - 13) | 84 | 76 | |
| 01/20/2022 | W | at | 132 | Georgia St. (18 - 10) | 61 | 60 | |
| 01/22/2022 | W | at | 248 | Georgia Southern (13 - 16) | 70 | 62 | |
| 01/27/2022 | W | 141 | Arkansas St. (18 - 11) | 61 | 54 | ||
| 01/29/2022 | W | 301 | Little Rock (9 - 19) | 72 | 57 | ||
| 02/03/2022 | L | at | 69 | Texas St. (21 - 7) | 66 | 68 | |
| 02/05/2022 | W | at | 257 | UT Arlington (11 - 18) | 70 | 61 | |
| 02/10/2022 | W | 248 | Georgia Southern (13 - 16) | 65 | 61 | ||
| 02/12/2022 | L | 132 | Georgia St. (18 - 10) | 49 | 58 | ||
| 02/17/2022 | L | 120 | Troy (20 - 11) | 61 | 67 | ||
| 02/19/2022 | W | 145 | South Alabama (19 - 11) | 69 | 51 | ||
| 02/23/2022 | W | at | 301 | Little Rock (9 - 19) | 78 | 66 | |
| 02/25/2022 | L | at | 141 | Arkansas St. (18 - 11) | 60 | 62 | |
| 03/05/2022 | W | 248 | Georgia Southern (13 - 16) | 73 | 60 | Pensacola, FL | |
| 03/06/2022 | L | 132 | Georgia St. (18 - 10) | 66 | 71 | Pensacola, FL |