| Team: | High Point | Rating: | -2.7931 | Average Socre: | 69.5313 |
| Conference: | Big South | ||||
| Wins: | 14 | Losses: | 18 | Div 1 Games: | 29 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | Shenandoah ( - ) | 108 | 59 | |||
| 11/12/2021 | L | at | 193 | Northwestern (15 - 16) | 60 | 95 | |
| 11/16/2021 | L | at | 61 | Notre Dame (22 - 10) | 61 | 70 | |
| 11/20/2021 | W | 225 | Howard (16 - 13) | 73 | 63 | ||
| 11/21/2021 | L | 132 | Georgia St. (18 - 10) | 66 | 74 | ||
| 11/27/2021 | W | Chowan ( - ) | 90 | 60 | |||
| 11/30/2021 | L | 77 | Furman (22 - 12) | 70 | 74 | ||
| 12/04/2021 | W | at | 286 | Elon (10 - 22) | 83 | 77 | |
| 12/07/2021 | W | Guilford ( - ) | 64 | 59 | |||
| 12/10/2021 | L | at | 268 | South Carolina St. (15 - 16) | 66 | 67 | Rock Hill, SC |
| 12/18/2021 | L | 85 | UNC Wilmington (23 - 9) | 69 | 71 | ||
| 12/21/2021 | W | 168 | Florida Atlantic (19 - 14) | 55 | 52 | ||
| 12/29/2021 | L | at | 49 | Michigan St. (22 - 12) | 68 | 81 | |
| 12/31/2021 | L | at | 13 | Kentucky (26 - 7) | 48 | 92 | |
| 01/12/2022 | L | at | 218 | USC Upstate (14 - 16) | 65 | 66 | |
| 01/15/2022 | W | 289 | North Carolina A&T (12 - 20) | 78 | 71 | ||
| 01/19/2022 | L | at | 353 | Charleston Southern (6 - 25) | 66 | 70 | |
| 01/22/2022 | L | at | 306 | Hampton (9 - 19) | 64 | 68 | |
| 01/24/2022 | W | 84 | Winthrop (23 - 9) | 65 | 56 | ||
| 01/26/2022 | W | 287 | Radford (11 - 18) | 63 | 58 | ||
| 01/29/2022 | L | at | 198 | Campbell (16 - 13) | 72 | 77 | |
| 02/02/2022 | L | 170 | Gardner Webb (18 - 13) | 57 | 65 | ||
| 02/05/2022 | W | 208 | UNC Asheville (16 - 14) | 91 | 83 | ||
| 02/09/2022 | W | at | 290 | Presbyterian (12 - 20) | 79 | 70 | |
| 02/12/2022 | L | 198 | Campbell (16 - 13) | 42 | 60 | ||
| 02/15/2022 | L | at | 56 | Longwood (26 - 6) | 66 | 70 | |
| 02/17/2022 | L | 56 | Longwood (26 - 6) | 71 | 78 | ||
| 02/19/2022 | L | at | 287 | Radford (11 - 18) | 64 | 66 | |
| 02/23/2022 | W | at | 289 | North Carolina A&T (12 - 20) | 78 | 58 | |
| 02/26/2022 | W | 306 | Hampton (9 - 19) | 88 | 77 | ||
| 03/02/2022 | W | 306 | Hampton (9 - 19) | 84 | 77 | Charlotte, NC | |
| 03/04/2022 | L | at | 84 | Winthrop (23 - 9) | 51 | 68 | Charlotte, NC |