| Team: | Winthrop | Rating: | 5.4828 | Average Socre: | 75.2188 |
| Conference: | Big South | ||||
| Wins: | 23 | Losses: | 9 | Div 1 Games: | 29 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | Mary Baldwin ( - ) | 110 | 78 | |||
| 11/13/2021 | W | 189 | Mercer (16 - 17) | 88 | 85 | ||
| 11/16/2021 | L | at | 62 | Middle Tennessee (23 - 10) | 65 | 76 | |
| 11/20/2021 | L | at | 134 | Vanderbilt (17 - 16) | 63 | 77 | |
| 11/22/2021 | L | at | 99 | Washington St. (19 - 14) | 86 | 92 | |
| 11/27/2021 | W | at | 136 | Washington (17 - 15) | 82 | 74 | |
| 12/01/2021 | W | 269 | Hartford (12 - 20) | 82 | 75 | ||
| 12/04/2021 | L | at | 166 | Coastal Carolina (16 - 13) | 64 | 74 | |
| 12/07/2021 | W | 77 | Furman (22 - 12) | 85 | 80 | ||
| 12/11/2021 | W | Carver ( - ) | 83 | 52 | |||
| 12/15/2021 | L | at | 286 | Elon (10 - 22) | 61 | 63 | |
| 12/21/2021 | L | at | 108 | Mississippi St. (18 - 15) | 63 | 84 | Jackson, MS |
| 12/31/2021 | W | Converse ( - ) | 78 | 40 | |||
| 01/10/2022 | W | 198 | Campbell (16 - 13) | 74 | 72 | ||
| 01/13/2022 | W | 208 | UNC Asheville (16 - 14) | 86 | 80 | ||
| 01/15/2022 | W | at | 353 | Charleston Southern (6 - 25) | 70 | 65 | |
| 01/20/2022 | W | at | 290 | Presbyterian (12 - 20) | 60 | 58 | |
| 01/22/2022 | W | 170 | Gardner Webb (18 - 13) | 64 | 62 | ||
| 01/24/2022 | L | at | 239 | High Point (14 - 18) | 56 | 65 | |
| 01/26/2022 | W | at | 218 | USC Upstate (14 - 16) | 95 | 91 | |
| 01/29/2022 | L | at | 56 | Longwood (26 - 6) | 88 | 92 | |
| 02/03/2022 | W | 289 | North Carolina A&T (12 - 20) | 64 | 54 | ||
| 02/05/2022 | W | at | 306 | Hampton (9 - 19) | 69 | 57 | |
| 02/09/2022 | W | 287 | Radford (11 - 18) | 58 | 48 | ||
| 02/12/2022 | W | 290 | Presbyterian (12 - 20) | 65 | 61 | ||
| 02/16/2022 | W | at | 170 | Gardner Webb (18 - 13) | 81 | 70 | |
| 02/19/2022 | W | at | 208 | UNC Asheville (16 - 14) | 84 | 79 | |
| 02/24/2022 | W | 218 | USC Upstate (14 - 16) | 89 | 59 | ||
| 02/26/2022 | W | 353 | Charleston Southern (6 - 25) | 92 | 86 | ||
| 03/04/2022 | W | 239 | High Point (14 - 18) | 68 | 51 | Charlotte, NC | |
| 03/05/2022 | W | 170 | Gardner Webb (18 - 13) | 76 | 67 | Charlotte, NC | |
| 03/06/2022 | L | at | 56 | Longwood (26 - 6) | 58 | 79 | Charlotte, NC |