| Team: | Presbyterian | Rating: | -5.3793 | Average Socre: | 67.8125 |
| Conference: | Big South | ||||
| Wins: | 12 | Losses: | 20 | Div 1 Games: | 29 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 156 | Clemson (17 - 16) | 53 | 64 | |
| 11/12/2021 | W | 181 | VMI (16 - 15) | 73 | 72 | ||
| 11/15/2021 | W | 244 | The Citadel (13 - 18) | 74 | 70 | ||
| 11/18/2021 | L | at | 157 | Cincinnati (18 - 15) | 45 | 79 | |
| 11/24/2021 | W | at | 181 | VMI (16 - 15) | 59 | 54 | New Orleans, LA |
| 11/25/2021 | W | at | 201 | New Orleans (18 - 13) | 68 | 66 | |
| 11/26/2021 | W | 279 | Central Arkansas (11 - 20) | 75 | 66 | New Orleans, LA | |
| 11/30/2021 | L | at | 6 | Tennessee (26 - 7) | 44 | 86 | |
| 12/03/2021 | W | Bob Jones ( - ) | 90 | 61 | |||
| 12/06/2021 | L | at | 96 | Morehead St. (23 - 11) | 66 | 71 | |
| 12/12/2021 | L | at | 160 | Charleston (17 - 15) | 76 | 78 | |
| 12/15/2021 | W | Carver ( - ) | 98 | 33 | |||
| 12/18/2021 | L | 142 | Wofford (19 - 13) | 49 | 76 | ||
| 12/21/2021 | L | at | 77 | Furman (22 - 12) | 61 | 75 | |
| 12/30/2021 | W | Truett McConnell ( - ) | 91 | 49 | |||
| 01/05/2022 | L | at | 289 | North Carolina A&T (12 - 20) | 57 | 65 | |
| 01/08/2022 | L | 218 | USC Upstate (14 - 16) | 72 | 82 | ||
| 01/12/2022 | L | at | 170 | Gardner Webb (18 - 13) | 61 | 64 | |
| 01/20/2022 | L | 84 | Winthrop (23 - 9) | 58 | 60 | ||
| 01/22/2022 | L | 56 | Longwood (26 - 6) | 70 | 71 | ||
| 01/26/2022 | W | at | 353 | Charleston Southern (6 - 25) | 62 | 61 | |
| 01/29/2022 | L | 208 | UNC Asheville (16 - 14) | 67 | 68 | ||
| 02/02/2022 | W | 198 | Campbell (16 - 13) | 64 | 58 | ||
| 02/05/2022 | W | at | 287 | Radford (11 - 18) | 78 | 70 | |
| 02/07/2022 | L | at | 306 | Hampton (9 - 19) | 69 | 74 | |
| 02/09/2022 | L | 239 | High Point (14 - 18) | 70 | 79 | ||
| 02/12/2022 | L | at | 84 | Winthrop (23 - 9) | 61 | 65 | |
| 02/16/2022 | L | at | 218 | USC Upstate (14 - 16) | 55 | 60 | |
| 02/19/2022 | L | 170 | Gardner Webb (18 - 13) | 68 | 76 | ||
| 02/23/2022 | W | 353 | Charleston Southern (6 - 25) | 68 | 48 | ||
| 02/26/2022 | L | at | 208 | UNC Asheville (16 - 14) | 96 | 98 | |
| 03/02/2022 | L | at | 198 | Campbell (16 - 13) | 72 | 75 | Charlotte, NC |