| Team: | Drake | Rating: | 6.3438 | Average Socre: | 73.4706 |
| Conference: | Missouri Valley | ||||
| Wins: | 24 | Losses: | 10 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | Coe ( - ) | 87 | 61 | |||
| 11/14/2021 | W | 150 | South Dakota (19 - 12) | 99 | 50 | ||
| 11/20/2021 | W | 58 | Richmond (23 - 12) | 73 | 70 | ||
| 11/25/2021 | L | 33 | Belmont (25 - 7) | 69 | 74 | Kissimmee, FL | |
| 11/26/2021 | L | 43 | Alabama (19 - 13) | 71 | 80 | Kissimmee, FL | |
| 11/28/2021 | L | 19 | North Texas (24 - 6) | 54 | 57 | Kissimmee, FL | |
| 12/02/2021 | W | 243 | Valparaiso (14 - 18) | 73 | 66 | ||
| 12/05/2021 | W | 315 | St. Thomas (10 - 20) | 74 | 64 | ||
| 12/08/2021 | W | at | 343 | Nebraska Omaha (5 - 25) | 78 | 70 | |
| 12/11/2021 | L | 156 | Clemson (17 - 16) | 80 | 90 | Atlanta, GA | |
| 12/16/2021 | W | 299 | Jackson St. (11 - 19) | 70 | 65 | ||
| 12/19/2021 | W | 332 | Tennessee Martin (8 - 22) | 80 | 54 | ||
| 12/22/2021 | W | 327 | Chicago St. (7 - 25) | 87 | 50 | ||
| 12/28/2021 | W | Mount Marty ( - ) | 82 | 53 | |||
| 01/02/2022 | L | at | 57 | Missouri St. (23 - 10) | 56 | 61 | |
| 01/08/2022 | W | at | 342 | Evansville (6 - 24) | 60 | 59 | |
| 01/12/2022 | W | 258 | Illinois St. (13 - 20) | 86 | 75 | ||
| 01/17/2022 | W | at | 183 | Southern Illinois (16 - 15) | 60 | 59 | |
| 01/19/2022 | L | 151 | Bradley (17 - 14) | 71 | 83 | ||
| 01/22/2022 | W | at | 82 | Northern Iowa (19 - 11) | 82 | 74 | |
| 01/26/2022 | W | at | 258 | Illinois St. (13 - 20) | 89 | 88 | |
| 01/30/2022 | W | 34 | Loyola Chicago (25 - 7) | 77 | 68 | ||
| 02/02/2022 | W | at | 297 | Indiana St. (11 - 20) | 85 | 67 | |
| 02/05/2022 | L | 82 | Northern Iowa (19 - 11) | 69 | 74 | ||
| 02/09/2022 | L | 57 | Missouri St. (23 - 10) | 62 | 66 | ||
| 02/12/2022 | L | at | 151 | Bradley (17 - 14) | 59 | 68 | |
| 02/16/2022 | W | 342 | Evansville (6 - 24) | 73 | 51 | ||
| 02/19/2022 | W | at | 34 | Loyola Chicago (25 - 7) | 83 | 76 | |
| 02/21/2022 | W | 297 | Indiana St. (11 - 20) | 74 | 58 | ||
| 02/23/2022 | W | at | 243 | Valparaiso (14 - 18) | 71 | 65 | |
| 02/26/2022 | W | 183 | Southern Illinois (16 - 15) | 62 | 60 | ||
| 03/04/2022 | W | 183 | Southern Illinois (16 - 15) | 65 | 52 | St. Louis, MO | |
| 03/05/2022 | W | at | 57 | Missouri St. (23 - 10) | 79 | 78 | St. Louis, MO |
| 03/06/2022 | L | 34 | Loyola Chicago (25 - 7) | 58 | 64 | St. Louis, MO |