| Team: | East Tennessee St. | Rating: | 0.2333 | Average Socre: | 72.0625 |
| Conference: | Southern | ||||
| Wins: | 15 | Losses: | 17 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/12/2021 | L | at | 122 | Appalachian St. (19 - 14) | 67 | 69 | |
| 11/14/2021 | L | at | 6 | Tennessee (26 - 7) | 62 | 94 | |
| 11/18/2021 | W | 218 | USC Upstate (14 - 16) | 56 | 43 | ||
| 11/22/2021 | W | at | 3 | Murray St. (30 - 2) | 66 | 58 | Naples, FL |
| 11/23/2021 | W | at | 57 | Missouri St. (23 - 10) | 77 | 76 | Naples, FL |
| 11/24/2021 | W | 73 | Kent St. (23 - 10) | 57 | 51 | Naples, FL | |
| 11/27/2021 | W | Lees McRae ( - ) | 92 | 74 | |||
| 12/01/2021 | L | at | 24 | UAB (27 - 7) | 56 | 70 | |
| 12/04/2021 | W | Lenoir Rhyne ( - ) | 90 | 66 | |||
| 12/11/2021 | W | 96 | Morehead St. (23 - 11) | 82 | 75 | ||
| 12/14/2021 | L | 289 | North Carolina A&T (12 - 20) | 67 | 69 | ||
| 12/18/2021 | L | at | 208 | UNC Asheville (16 - 14) | 64 | 79 | |
| 12/22/2021 | W | at | 320 | Georgia (6 - 26) | 86 | 84 | |
| 12/30/2021 | L | at | 22 | Chattanooga (27 - 7) | 52 | 82 | |
| 01/05/2022 | W | 181 | VMI (16 - 15) | 80 | 79 | ||
| 01/08/2022 | L | 142 | Wofford (19 - 13) | 57 | 68 | ||
| 01/10/2022 | W | 273 | Western Carolina (11 - 21) | 87 | 69 | ||
| 01/12/2022 | L | at | 77 | Furman (22 - 12) | 69 | 78 | |
| 01/15/2022 | W | at | 105 | Samford (21 - 11) | 88 | 85 | |
| 01/19/2022 | W | 189 | Mercer (16 - 17) | 72 | 64 | ||
| 01/22/2022 | L | 244 | The Citadel (13 - 18) | 73 | 75 | ||
| 01/26/2022 | L | 149 | UNC Greensboro (17 - 14) | 76 | 80 | ||
| 01/29/2022 | L | at | 181 | VMI (16 - 15) | 79 | 83 | |
| 02/02/2022 | L | at | 273 | Western Carolina (11 - 21) | 84 | 87 | |
| 02/05/2022 | L | at | 142 | Wofford (19 - 13) | 60 | 62 | |
| 02/07/2022 | W | 77 | Furman (22 - 12) | 75 | 71 | ||
| 02/12/2022 | L | 105 | Samford (21 - 11) | 73 | 77 | ||
| 02/16/2022 | L | at | 189 | Mercer (16 - 17) | 56 | 65 | |
| 02/19/2022 | W | at | 244 | The Citadel (13 - 18) | 77 | 67 | |
| 02/23/2022 | L | 22 | Chattanooga (27 - 7) | 77 | 83 | ||
| 02/27/2022 | W | at | 149 | UNC Greensboro (17 - 14) | 73 | 69 | |
| 03/04/2022 | L | 244 | The Citadel (13 - 18) | 76 | 84 | Asheville, NC |