| Team: | Penn | Rating: | -1.7857 | Average Socre: | 72.0357 |
| Conference: | Ivy | ||||
| Wins: | 12 | Losses: | 16 | Div 1 Games: | 28 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | L | at | 133 | Florida St. (17 - 14) | 70 | 105 | |
| 11/12/2021 | L | at | 191 | George Mason (14 - 16) | 66 | 87 | |
| 11/14/2021 | W | at | 324 | Bucknell (9 - 23) | 73 | 68 | |
| 11/16/2021 | W | 304 | Lafayette (10 - 20) | 85 | 57 | ||
| 11/18/2021 | L | at | 110 | Utah St. (18 - 15) | 79 | 87 | Conway, SC |
| 11/19/2021 | L | 28 | Davidson (27 - 6) | 60 | 72 | Conway, SC | |
| 11/21/2021 | W | at | 221 | Old Dominion (13 - 19) | 71 | 63 | Conway, SC |
| 11/23/2021 | L | at | 47 | Towson (25 - 8) | 61 | 76 | |
| 11/28/2021 | L | at | 27 | Arkansas (25 - 8) | 60 | 76 | |
| 12/01/2021 | L | 14 | Villanova (26 - 7) | 56 | 71 | ||
| 12/04/2021 | L | at | 124 | Temple (17 - 12) | 72 | 81 | |
| 12/08/2021 | L | at | 246 | Saint Joseph's (11 - 19) | 71 | 78 | |
| 12/11/2021 | L | at | 271 | La Salle (11 - 19) | 74 | 76 | |
| 01/02/2022 | W | 224 | Brown (13 - 16) | 77 | 73 | ||
| 01/07/2022 | W | 178 | Cornell (15 - 11) | 79 | 65 | ||
| 01/08/2022 | L | 349 | Columbia (4 - 22) | 69 | 73 | ||
| 01/15/2022 | W | 282 | Dartmouth (9 - 16) | 78 | 68 | ||
| 01/17/2022 | L | at | 71 | Princeton (23 - 6) | 64 | 74 | |
| 01/22/2022 | W | 101 | Yale (19 - 11) | 76 | 68 | ||
| 01/28/2022 | W | at | 223 | Harvard (13 - 13) | 78 | 74 | |
| 02/04/2022 | W | at | 349 | Columbia (4 - 22) | 81 | 66 | |
| 02/05/2022 | W | at | 178 | Cornell (15 - 11) | 73 | 68 | |
| 02/12/2022 | W | 223 | Harvard (13 - 13) | 82 | 74 | ||
| 02/18/2022 | L | at | 101 | Yale (19 - 11) | 72 | 81 | |
| 02/19/2022 | W | at | 224 | Brown (13 - 16) | 89 | 88 | |
| 02/26/2022 | L | at | 282 | Dartmouth (9 - 16) | 70 | 84 | |
| 03/05/2022 | L | 71 | Princeton (23 - 6) | 70 | 93 | ||
| 03/12/2022 | L | at | 101 | Yale (19 - 11) | 61 | 67 | Boston, MA |