| Team: | Purdue | Rating: | 11.4706 | Average Socre: | 79.7941 |
| Conference: | Big Ten | ||||
| Wins: | 27 | Losses: | 7 | Div 1 Games: | 34 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 127 | Bellarmine (20 - 13) | 96 | 67 | ||
| 11/12/2021 | W | 297 | Indiana St. (11 - 20) | 92 | 67 | ||
| 11/16/2021 | W | 139 | Wright St. (21 - 13) | 96 | 52 | ||
| 11/20/2021 | W | 37 | North Carolina (24 - 9) | 93 | 84 | Uncasville, CT | |
| 11/21/2021 | W | 14 | Villanova (26 - 7) | 80 | 74 | Uncasville, CT | |
| 11/26/2021 | W | 343 | Nebraska Omaha (5 - 25) | 97 | 40 | ||
| 11/30/2021 | W | 133 | Florida St. (17 - 14) | 93 | 65 | ||
| 12/03/2021 | W | 30 | Iowa (26 - 9) | 77 | 70 | ||
| 12/09/2021 | L | at | 109 | Rutgers (18 - 13) | 68 | 70 | |
| 12/12/2021 | W | at | 249 | N.C. State (11 - 21) | 82 | 72 | Brooklyn, NY |
| 12/18/2021 | W | at | 205 | Butler (14 - 19) | 77 | 48 | Indianapolis, IN |
| 12/20/2021 | W | 339 | Incarnate Word (7 - 25) | 79 | 59 | ||
| 12/29/2021 | W | 152 | Nicholls St. (21 - 11) | 104 | 90 | ||
| 01/03/2022 | L | 18 | Wisconsin (24 - 7) | 69 | 74 | ||
| 01/08/2022 | W | at | 175 | Penn St. (14 - 17) | 74 | 67 | |
| 01/14/2022 | W | 265 | Nebraska (10 - 22) | 92 | 65 | ||
| 01/17/2022 | W | at | 38 | Illinois (22 - 9) | 96 | 88 | |
| 01/20/2022 | L | at | 92 | Indiana (20 - 13) | 65 | 68 | |
| 01/23/2022 | W | 193 | Northwestern (15 - 16) | 80 | 60 | ||
| 01/27/2022 | W | at | 30 | Iowa (26 - 9) | 83 | 73 | |
| 01/30/2022 | W | 76 | Ohio St. (19 - 11) | 81 | 78 | ||
| 02/02/2022 | W | at | 179 | Minnesota (13 - 17) | 88 | 73 | |
| 02/05/2022 | W | 87 | Michigan (17 - 14) | 82 | 76 | ||
| 02/08/2022 | W | 38 | Illinois (22 - 9) | 84 | 68 | ||
| 02/10/2022 | L | at | 87 | Michigan (17 - 14) | 58 | 82 | |
| 02/13/2022 | W | 163 | Maryland (15 - 17) | 62 | 61 | ||
| 02/16/2022 | W | at | 193 | Northwestern (15 - 16) | 70 | 64 | |
| 02/20/2022 | W | 109 | Rutgers (18 - 13) | 84 | 72 | ||
| 02/26/2022 | L | at | 49 | Michigan St. (22 - 12) | 65 | 68 | |
| 03/01/2022 | L | at | 18 | Wisconsin (24 - 7) | 67 | 70 | |
| 03/05/2022 | W | 92 | Indiana (20 - 13) | 69 | 67 | ||
| 03/11/2022 | W | 175 | Penn St. (14 - 17) | 69 | 61 | Indianapolis, IN | |
| 03/12/2022 | W | 49 | Michigan St. (22 - 12) | 75 | 70 | Indianapolis, IN | |
| 03/13/2022 | L | 30 | Iowa (26 - 9) | 66 | 75 | Indianapolis, IN |