| Team: | Middle Tennessee | Rating: | 6.5484 | Average Socre: | 74.4242 |
| Conference: | Conference USA | ||||
| Wins: | 23 | Losses: | 10 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | Brescia ( - ) | 98 | 59 | |||
| 11/12/2021 | W | 337 | Bethune Cookman (9 - 21) | 71 | 51 | ||
| 11/16/2021 | W | 84 | Winthrop (23 - 9) | 76 | 65 | ||
| 11/19/2021 | L | at | 60 | Stephen F. Austin (22 - 9) | 74 | 87 | |
| 11/23/2021 | W | at | 252 | Rider (14 - 19) | 60 | 54 | Riviera Maya, Mexico |
| 11/24/2021 | W | at | 189 | Mercer (16 - 17) | 82 | 58 | Riviera Maya, Mexico |
| 11/27/2021 | W | Bryan ( - ) | 96 | 48 | |||
| 12/01/2021 | W | 332 | Tennessee Martin (8 - 22) | 73 | 61 | ||
| 12/04/2021 | L | at | 3 | Murray St. (30 - 2) | 87 | 93 | |
| 12/11/2021 | W | at | 332 | Tennessee Martin (8 - 22) | 84 | 75 | |
| 12/15/2021 | L | at | 209 | Mississippi (13 - 19) | 52 | 62 | |
| 12/19/2021 | W | 166 | Coastal Carolina (16 - 13) | 84 | 80 | ||
| 12/22/2021 | L | at | 22 | Chattanooga (27 - 7) | 65 | 77 | |
| 01/06/2022 | L | at | 188 | Rice (16 - 16) | 61 | 65 | |
| 01/08/2022 | L | at | 19 | North Texas (24 - 6) | 63 | 70 | |
| 01/13/2022 | W | 168 | Florida Atlantic (19 - 14) | 70 | 57 | ||
| 01/15/2022 | W | 250 | FIU (15 - 17) | 50 | 39 | ||
| 01/22/2022 | W | 340 | Southern Miss (7 - 26) | 74 | 60 | ||
| 01/27/2022 | W | at | 261 | Marshall (12 - 21) | 81 | 79 | |
| 01/29/2022 | W | at | 144 | Western Kentucky (19 - 13) | 93 | 85 | |
| 02/05/2022 | L | at | 24 | UAB (27 - 7) | 75 | 97 | |
| 02/07/2022 | W | 323 | UTSA (10 - 22) | 84 | 75 | ||
| 02/10/2022 | W | 221 | Old Dominion (13 - 19) | 63 | 48 | ||
| 02/13/2022 | W | 138 | Charlotte (17 - 14) | 78 | 63 | ||
| 02/17/2022 | W | at | 250 | FIU (15 - 17) | 71 | 65 | |
| 02/19/2022 | W | at | 168 | Florida Atlantic (19 - 14) | 87 | 79 | |
| 02/21/2022 | W | 116 | UTEP (19 - 13) | 77 | 59 | ||
| 02/24/2022 | W | 261 | Marshall (12 - 21) | 74 | 65 | ||
| 02/26/2022 | W | 144 | Western Kentucky (19 - 13) | 69 | 52 | ||
| 03/02/2022 | L | at | 138 | Charlotte (17 - 14) | 56 | 60 | |
| 03/05/2022 | L | at | 221 | Old Dominion (13 - 19) | 64 | 68 | |
| 03/10/2022 | W | 116 | UTEP (19 - 13) | 66 | 59 | Frisco, TX | |
| 03/11/2022 | L | 24 | UAB (27 - 7) | 98 | 102 | Frisco, TX |