| Team: | Charleston | Rating: | 1.7188 | Average Socre: | 78.1875 |
| Conference: | Colonial | ||||
| Wins: | 17 | Losses: | 15 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/11/2021 | W | 268 | South Carolina St. (15 - 16) | 106 | 74 | ||
| 11/12/2021 | W | 263 | Lipscomb (14 - 19) | 86 | 77 | ||
| 11/13/2021 | W | 242 | Loyola MD (14 - 16) | 79 | 72 | ||
| 11/16/2021 | L | 37 | North Carolina (24 - 9) | 83 | 94 | ||
| 11/22/2021 | L | at | 126 | Oklahoma St. (15 - 15) | 66 | 96 | |
| 11/27/2021 | W | at | 22 | Chattanooga (27 - 7) | 68 | 66 | |
| 11/30/2021 | W | 159 | Tulane (14 - 15) | 81 | 77 | ||
| 12/03/2021 | L | at | 77 | Furman (22 - 12) | 88 | 91 | |
| 12/07/2021 | W | at | 159 | Tulane (14 - 15) | 86 | 72 | |
| 12/12/2021 | W | 290 | Presbyterian (12 - 20) | 78 | 76 | ||
| 12/16/2021 | L | at | 312 | Stetson (11 - 19) | 59 | 67 | |
| 12/22/2021 | W | at | 221 | Old Dominion (13 - 19) | 82 | 80 | |
| 12/31/2021 | L | 91 | Delaware (22 - 12) | 66 | 67 | ||
| 01/09/2022 | W | 286 | Elon (10 - 22) | 65 | 61 | ||
| 01/17/2022 | L | 85 | UNC Wilmington (23 - 9) | 78 | 86 | ||
| 01/20/2022 | L | at | 47 | Towson (25 - 8) | 67 | 74 | |
| 01/22/2022 | L | at | 182 | James Madison (15 - 14) | 94 | 95 | |
| 01/25/2022 | W | 346 | William & Mary (5 - 27) | 74 | 73 | ||
| 01/27/2022 | L | 89 | Hofstra (21 - 11) | 73 | 76 | ||
| 01/29/2022 | W | 281 | Northeastern (9 - 22) | 81 | 63 | ||
| 02/03/2022 | W | at | 346 | William & Mary (5 - 27) | 84 | 61 | |
| 02/05/2022 | W | at | 286 | Elon (10 - 22) | 66 | 64 | |
| 02/12/2022 | L | at | 85 | UNC Wilmington (23 - 9) | 79 | 85 | |
| 02/14/2022 | W | 185 | Drexel (15 - 14) | 79 | 75 | ||
| 02/17/2022 | L | 182 | James Madison (15 - 14) | 63 | 71 | ||
| 02/19/2022 | L | 47 | Towson (25 - 8) | 77 | 80 | ||
| 02/22/2022 | W | at | 281 | Northeastern (9 - 22) | 83 | 72 | |
| 02/24/2022 | W | at | 91 | Delaware (22 - 12) | 99 | 96 | |
| 02/26/2022 | L | at | 185 | Drexel (15 - 14) | 79 | 80 | |
| 02/28/2022 | L | at | 89 | Hofstra (21 - 11) | 84 | 89 | |
| 03/06/2022 | W | at | 89 | Hofstra (21 - 11) | 92 | 76 | Washington, DC |
| 03/07/2022 | L | at | 85 | UNC Wilmington (23 - 9) | 57 | 60 | Washington, DC |