| Team: | Tennessee St. | Rating: | -4.5667 | Average Socre: | 71.3125 |
| Conference: | Ohio Valley | ||||
| Wins: | 14 | Losses: | 18 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 292 | Alabama A&M (12 - 18) | 73 | 82 | |
| 11/13/2021 | L | 86 | Norfolk St. (24 - 6) | 59 | 66 | Atlanta, GA | |
| 11/16/2021 | W | Fisk ( - ) | 111 | 56 | |||
| 11/21/2021 | L | at | 150 | South Dakota (19 - 12) | 66 | 83 | |
| 11/23/2021 | L | at | 265 | Nebraska (10 - 22) | 73 | 79 | |
| 11/28/2021 | L | 212 | Southern (17 - 14) | 80 | 82 | ||
| 12/04/2021 | L | at | 327 | Chicago St. (7 - 25) | 49 | 59 | |
| 12/10/2021 | W | 358 | IUPUI (3 - 26) | 70 | 44 | ||
| 12/12/2021 | W | at | 263 | Lipscomb (14 - 19) | 73 | 65 | |
| 12/16/2021 | W | at | 353 | Charleston Southern (6 - 25) | 78 | 75 | |
| 12/18/2021 | L | at | 268 | South Carolina St. (15 - 16) | 88 | 90 | |
| 12/21/2021 | W | Campbellsville H'burg ( - ) | 108 | 66 | |||
| 01/06/2022 | L | 332 | Tennessee Martin (8 - 22) | 78 | 94 | ||
| 01/08/2022 | W | 234 | Southeast Missouri St. (14 - 18) | 95 | 84 | ||
| 01/13/2022 | L | at | 3 | Murray St. (30 - 2) | 44 | 67 | |
| 01/15/2022 | L | 96 | Morehead St. (23 - 11) | 64 | 71 | ||
| 01/17/2022 | W | 291 | Tennessee Tech (11 - 21) | 80 | 64 | ||
| 01/20/2022 | L | at | 234 | Southeast Missouri St. (14 - 18) | 63 | 85 | |
| 01/22/2022 | W | 275 | Austin Peay (12 - 17) | 65 | 61 | ||
| 01/24/2022 | L | at | 96 | Morehead St. (23 - 11) | 54 | 67 | |
| 01/27/2022 | W | at | 302 | SIU Edwardsville (11 - 21) | 75 | 70 | |
| 01/29/2022 | L | at | 354 | Eastern Illinois (5 - 26) | 57 | 62 | |
| 02/03/2022 | L | 33 | Belmont (25 - 7) | 61 | 88 | ||
| 02/05/2022 | W | at | 332 | Tennessee Martin (8 - 22) | 69 | 61 | |
| 02/10/2022 | L | 3 | Murray St. (30 - 2) | 62 | 73 | ||
| 02/12/2022 | L | at | 275 | Austin Peay (12 - 17) | 52 | 54 | |
| 02/17/2022 | W | 302 | SIU Edwardsville (11 - 21) | 81 | 65 | ||
| 02/19/2022 | W | 354 | Eastern Illinois (5 - 26) | 63 | 49 | ||
| 02/24/2022 | W | at | 291 | Tennessee Tech (11 - 21) | 92 | 56 | |
| 02/26/2022 | L | at | 33 | Belmont (25 - 7) | 67 | 87 | |
| 03/02/2022 | W | 302 | SIU Edwardsville (11 - 21) | 77 | 62 | Evansville, IN | |
| 03/03/2022 | L | at | 234 | Southeast Missouri St. (14 - 18) | 55 | 79 | Evansville, IN |