| Team: | Prairie View A&M | Rating: | -6.5926 | Average Socre: | 69.5185 |
| Conference: | Southwestern | ||||
| Wins: | 8 | Losses: | 19 | Div 1 Games: | 27 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 11 | Saint Mary's (25 - 7) | 68 | 87 | |
| 11/11/2021 | L | at | 23 | San Francisco (24 - 9) | 76 | 92 | |
| 11/13/2021 | L | at | 87 | Michigan (17 - 14) | 49 | 77 | Washington, DC |
| 11/14/2021 | L | at | 126 | Oklahoma St. (15 - 15) | 59 | 72 | |
| 11/15/2021 | L | at | 31 | Texas Tech (25 - 9) | 49 | 84 | |
| 11/17/2021 | L | at | 53 | Grand Canyon (23 - 8) | 64 | 91 | |
| 11/27/2021 | L | at | 226 | Loyola Marymount (11 - 18) | 80 | 83 | |
| 11/30/2021 | L | at | 17 | South Dakota St. (30 - 4) | 90 | 99 | |
| 12/10/2021 | L | at | 20 | Boise St. (27 - 7) | 60 | 97 | |
| 12/22/2021 | L | at | 128 | Wichita St. (15 - 13) | 66 | 102 | |
| 01/08/2022 | L | 356 | Mississippi Valley St. (2 - 26) | 82 | 84 | ||
| 01/10/2022 | W | 347 | Arkansas Pine Bluff (7 - 24) | 75 | 58 | ||
| 01/15/2022 | L | at | 299 | Jackson St. (11 - 19) | 64 | 75 | |
| 01/17/2022 | W | at | 213 | Alcorn St. (17 - 16) | 74 | 73 | |
| 01/22/2022 | W | 328 | Alabama St. (10 - 21) | 70 | 67 | ||
| 01/24/2022 | W | 292 | Alabama A&M (12 - 18) | 72 | 48 | ||
| 01/29/2022 | L | 187 | Texas Southern (18 - 12) | 74 | 75 | ||
| 02/05/2022 | L | at | 337 | Bethune Cookman (9 - 21) | 67 | 68 | |
| 02/07/2022 | L | at | 278 | Florida A&M (13 - 17) | 60 | 61 | |
| 02/12/2022 | W | 212 | Southern (17 - 14) | 84 | 77 | ||
| 02/14/2022 | W | 294 | Grambling St. (12 - 20) | 71 | 70 | ||
| 02/19/2022 | W | at | 347 | Arkansas Pine Bluff (7 - 24) | 92 | 84 | |
| 02/21/2022 | W | at | 356 | Mississippi Valley St. (2 - 26) | 69 | 64 | |
| 02/26/2022 | L | 213 | Alcorn St. (17 - 16) | 69 | 72 | ||
| 02/28/2022 | L | 299 | Jackson St. (11 - 19) | 53 | 59 | ||
| 03/05/2022 | L | at | 187 | Texas Southern (18 - 12) | 77 | 78 | |
| 03/09/2022 | L | at | 213 | Alcorn St. (17 - 16) | 63 | 64 | Birmingham, AL |