| Team: | Grambling St. | Rating: | -5.6667 | Average Socre: | 65.375 |
| Conference: | Southwestern | ||||
| Wins: | 12 | Losses: | 20 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 53 | Grand Canyon (23 - 8) | 53 | 74 | |
| 11/12/2021 | L | at | 31 | Texas Tech (25 - 9) | 62 | 88 | |
| 11/15/2021 | L | at | 203 | New Mexico (13 - 19) | 61 | 86 | |
| 11/21/2021 | L | at | 81 | Iowa St. (20 - 12) | 47 | 82 | |
| 11/24/2021 | W | Louisiana College ( - ) | 71 | 61 | |||
| 11/28/2021 | W | 256 | Morgan St. (13 - 14) | 74 | 59 | Phoenix, AZ | |
| 11/29/2021 | L | 86 | Norfolk St. (24 - 6) | 63 | 70 | Phoenix, AZ | |
| 12/02/2021 | W | Jarvis Christian ( - ) | 71 | 44 | |||
| 12/04/2021 | L | at | 40 | Connecticut (23 - 9) | 59 | 88 | |
| 12/11/2021 | L | at | 339 | Incarnate Word (7 - 25) | 62 | 72 | |
| 12/14/2021 | L | at | 24 | UAB (27 - 7) | 61 | 79 | |
| 12/21/2021 | L | at | 72 | TCU (20 - 12) | 55 | 90 | |
| 12/28/2021 | L | at | 183 | Southern Illinois (16 - 15) | 64 | 75 | |
| 01/05/2022 | L | 187 | Texas Southern (18 - 12) | 61 | 67 | ||
| 01/08/2022 | W | at | 337 | Bethune Cookman (9 - 21) | 68 | 66 | |
| 01/10/2022 | L | at | 278 | Florida A&M (13 - 17) | 66 | 75 | |
| 01/15/2022 | W | 212 | Southern (17 - 14) | 83 | 77 | ||
| 01/22/2022 | W | 356 | Mississippi Valley St. (2 - 26) | 68 | 64 | ||
| 01/24/2022 | W | 347 | Arkansas Pine Bluff (7 - 24) | 76 | 65 | ||
| 01/29/2022 | W | at | 299 | Jackson St. (11 - 19) | 73 | 64 | Mobile, AL |
| 01/31/2022 | W | at | 213 | Alcorn St. (17 - 16) | 80 | 73 | |
| 02/05/2022 | L | 328 | Alabama St. (10 - 21) | 72 | 80 | ||
| 02/07/2022 | W | 292 | Alabama A&M (12 - 18) | 58 | 50 | ||
| 02/12/2022 | L | at | 187 | Texas Southern (18 - 12) | 65 | 68 | |
| 02/14/2022 | L | at | 305 | Prairie View A&M (8 - 19) | 70 | 71 | |
| 02/19/2022 | W | at | 212 | Southern (17 - 14) | 61 | 57 | |
| 02/26/2022 | L | 278 | Florida A&M (13 - 17) | 73 | 79 | ||
| 02/28/2022 | L | 337 | Bethune Cookman (9 - 21) | 63 | 69 | ||
| 03/03/2022 | L | at | 292 | Alabama A&M (12 - 18) | 63 | 71 | |
| 03/05/2022 | L | at | 328 | Alabama St. (10 - 21) | 75 | 78 | |
| 03/10/2022 | W | at | 212 | Southern (17 - 14) | 60 | 58 | Birmingham, AL |
| 03/11/2022 | L | at | 187 | Texas Southern (18 - 12) | 54 | 73 | Birmingham, AL |