| Team: | Mississippi Valley St. | Rating: | -14.5 | Average Socre: | 67.2143 |
| Conference: | Southwestern | ||||
| Wins: | 2 | Losses: | 26 | Div 1 Games: | 28 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 143 | St. John's (17 - 15) | 61 | 119 | |
| 11/13/2021 | L | at | 206 | Cal Baptist (18 - 15) | 66 | 95 | |
| 11/26/2021 | L | at | 209 | Mississippi (13 - 19) | 58 | 73 | |
| 11/29/2021 | L | at | 134 | Vanderbilt (17 - 16) | 36 | 75 | |
| 12/01/2021 | L | at | 338 | North Alabama (9 - 21) | 58 | 72 | |
| 12/04/2021 | L | at | 53 | Grand Canyon (23 - 8) | 44 | 91 | |
| 12/09/2021 | L | 152 | Nicholls St. (21 - 11) | 80 | 95 | ||
| 12/11/2021 | L | 141 | Arkansas St. (18 - 11) | 77 | 82 | ||
| 12/18/2021 | L | at | 152 | Nicholls St. (21 - 11) | 73 | 104 | |
| 12/22/2021 | L | at | 24 | UAB (27 - 7) | 58 | 100 | |
| 01/03/2022 | L | 328 | Alabama St. (10 - 21) | 75 | 84 | ||
| 01/05/2022 | L | 292 | Alabama A&M (12 - 18) | 67 | 72 | ||
| 01/08/2022 | W | at | 305 | Prairie View A&M (8 - 19) | 84 | 82 | |
| 01/10/2022 | L | at | 187 | Texas Southern (18 - 12) | 58 | 95 | |
| 01/15/2022 | L | 337 | Bethune Cookman (9 - 21) | 60 | 62 | ||
| 01/17/2022 | L | 278 | Florida A&M (13 - 17) | 70 | 78 | ||
| 01/22/2022 | L | at | 294 | Grambling St. (12 - 20) | 64 | 68 | |
| 01/24/2022 | L | at | 212 | Southern (17 - 14) | 72 | 100 | |
| 01/29/2022 | L | 347 | Arkansas Pine Bluff (7 - 24) | 68 | 74 | ||
| 02/05/2022 | L | 299 | Jackson St. (11 - 19) | 65 | 69 | ||
| 02/07/2022 | L | 213 | Alcorn St. (17 - 16) | 71 | 79 | ||
| 02/12/2022 | L | at | 292 | Alabama A&M (12 - 18) | 92 | 94 | |
| 02/14/2022 | W | at | 328 | Alabama St. (10 - 21) | 85 | 71 | |
| 02/19/2022 | L | 187 | Texas Southern (18 - 12) | 59 | 79 | ||
| 02/21/2022 | L | 305 | Prairie View A&M (8 - 19) | 64 | 69 | ||
| 02/26/2022 | L | at | 347 | Arkansas Pine Bluff (7 - 24) | 79 | 93 | |
| 03/03/2022 | L | at | 213 | Alcorn St. (17 - 16) | 69 | 72 | |
| 03/05/2022 | L | at | 299 | Jackson St. (11 - 19) | 69 | 76 |