| Team: | Texas Southern | Rating: | 0.2 | Average Socre: | 69.2333 |
| Conference: | Southwestern | ||||
| Wins: | 18 | Losses: | 12 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 112 | Oregon (19 - 14) | 66 | 83 | |
| 11/12/2021 | L | at | 11 | Saint Mary's (25 - 7) | 58 | 67 | |
| 11/15/2021 | L | at | 136 | Washington (17 - 15) | 65 | 72 | |
| 11/17/2021 | L | at | 240 | Air Force (11 - 18) | 57 | 61 | |
| 11/21/2021 | L | at | 249 | N.C. State (11 - 21) | 57 | 65 | |
| 11/24/2021 | L | at | 54 | BYU (22 - 10) | 64 | 81 | |
| 12/01/2021 | L | at | 67 | Louisiana Tech (24 - 10) | 60 | 87 | |
| 12/06/2021 | W | at | 106 | Florida (19 - 13) | 69 | 54 | |
| 12/14/2021 | W | at | 322 | UT Rio Grande Valley (8 - 23) | 70 | 60 | |
| 01/03/2022 | L | at | 212 | Southern (17 - 14) | 50 | 63 | |
| 01/05/2022 | W | at | 294 | Grambling St. (12 - 20) | 67 | 61 | |
| 01/08/2022 | W | 347 | Arkansas Pine Bluff (7 - 24) | 90 | 71 | ||
| 01/10/2022 | W | 356 | Mississippi Valley St. (2 - 26) | 95 | 58 | ||
| 01/15/2022 | L | at | 213 | Alcorn St. (17 - 16) | 72 | 73 | |
| 01/17/2022 | L | at | 299 | Jackson St. (11 - 19) | 58 | 61 | |
| 01/22/2022 | W | 292 | Alabama A&M (12 - 18) | 78 | 44 | ||
| 01/24/2022 | W | 328 | Alabama St. (10 - 21) | 73 | 66 | ||
| 01/29/2022 | W | at | 305 | Prairie View A&M (8 - 19) | 75 | 74 | |
| 02/05/2022 | W | at | 278 | Florida A&M (13 - 17) | 67 | 55 | |
| 02/07/2022 | W | at | 337 | Bethune Cookman (9 - 21) | 66 | 63 | |
| 02/12/2022 | W | 294 | Grambling St. (12 - 20) | 68 | 65 | ||
| 02/14/2022 | L | 212 | Southern (17 - 14) | 58 | 70 | ||
| 02/19/2022 | W | at | 356 | Mississippi Valley St. (2 - 26) | 79 | 59 | |
| 02/21/2022 | W | at | 347 | Arkansas Pine Bluff (7 - 24) | 70 | 68 | |
| 02/26/2022 | W | 299 | Jackson St. (11 - 19) | 81 | 66 | ||
| 02/28/2022 | L | 213 | Alcorn St. (17 - 16) | 72 | 75 | ||
| 03/05/2022 | W | 305 | Prairie View A&M (8 - 19) | 78 | 77 | ||
| 03/09/2022 | W | 299 | Jackson St. (11 - 19) | 54 | 50 | Birmingham, AL | |
| 03/11/2022 | W | 294 | Grambling St. (12 - 20) | 73 | 54 | Birmingham, AL | |
| 03/12/2022 | W | at | 213 | Alcorn St. (17 - 16) | 87 | 62 | Birmingham, AL |