| Team: | Iowa St. | Rating: | 5.6563 | Average Socre: | 66.4688 |
| Conference: | Big 12 | ||||
| Wins: | 20 | Losses: | 12 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 274 | Kennesaw St. (13 - 18) | 84 | 73 | ||
| 11/12/2021 | W | 344 | Oregon St. (3 - 28) | 60 | 50 | ||
| 11/16/2021 | W | 328 | Alabama St. (10 - 21) | 68 | 60 | ||
| 11/21/2021 | W | 294 | Grambling St. (12 - 20) | 82 | 47 | ||
| 11/24/2021 | W | at | 83 | Xavier (18 - 13) | 82 | 70 | Brooklyn, NY |
| 11/26/2021 | W | at | 45 | Memphis (21 - 10) | 78 | 59 | Brooklyn, NY |
| 12/01/2021 | W | 347 | Arkansas Pine Bluff (7 - 24) | 83 | 64 | ||
| 12/04/2021 | W | at | 51 | Creighton (22 - 11) | 64 | 58 | |
| 12/09/2021 | W | 30 | Iowa (26 - 9) | 73 | 53 | ||
| 12/12/2021 | W | 299 | Jackson St. (11 - 19) | 47 | 37 | ||
| 12/19/2021 | W | 174 | Southeastern Louisiana (19 - 14) | 77 | 54 | ||
| 12/21/2021 | W | 327 | Chicago St. (7 - 25) | 79 | 48 | ||
| 01/01/2022 | L | 12 | Baylor (26 - 6) | 72 | 77 | ||
| 01/05/2022 | W | 31 | Texas Tech (25 - 9) | 51 | 47 | ||
| 01/08/2022 | L | at | 103 | Oklahoma (18 - 15) | 66 | 79 | |
| 01/11/2022 | L | at | 4 | Kansas (28 - 6) | 61 | 62 | |
| 01/15/2022 | W | 55 | Texas (21 - 11) | 79 | 70 | ||
| 01/18/2022 | L | at | 31 | Texas Tech (25 - 9) | 60 | 72 | |
| 01/22/2022 | L | 72 | TCU (20 - 12) | 44 | 59 | ||
| 01/26/2022 | W | at | 126 | Oklahoma St. (15 - 15) | 84 | 81 | |
| 01/29/2022 | W | 238 | Missouri (12 - 21) | 67 | 50 | ||
| 02/01/2022 | L | 4 | Kansas (28 - 6) | 61 | 70 | ||
| 02/05/2022 | L | at | 55 | Texas (21 - 11) | 41 | 63 | |
| 02/08/2022 | L | at | 130 | West Virginia (16 - 17) | 63 | 79 | |
| 02/12/2022 | L | 192 | Kansas St. (14 - 17) | 69 | 75 | ||
| 02/15/2022 | W | at | 72 | TCU (20 - 12) | 54 | 51 | |
| 02/19/2022 | W | 103 | Oklahoma (18 - 15) | 75 | 54 | ||
| 02/23/2022 | W | 130 | West Virginia (16 - 17) | 84 | 81 | ||
| 02/26/2022 | W | at | 192 | Kansas St. (14 - 17) | 74 | 73 | |
| 03/02/2022 | L | 126 | Oklahoma St. (15 - 15) | 36 | 53 | ||
| 03/05/2022 | L | at | 12 | Baylor (26 - 6) | 68 | 75 | |
| 03/10/2022 | L | at | 31 | Texas Tech (25 - 9) | 41 | 72 | Kansas City, MO |