| Team: | Southern Illinois | Rating: | 0.2333 | Average Socre: | 64.0323 |
| Conference: | Missouri Valley | ||||
| Wins: | 16 | Losses: | 15 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 301 | Little Rock (9 - 19) | 66 | 69 | |
| 11/12/2021 | W | 275 | Austin Peay (12 - 17) | 73 | 55 | ||
| 11/19/2021 | W | at | 79 | Colorado (21 - 11) | 67 | 63 | St. Thomas, VI |
| 11/21/2021 | L | 281 | Northeastern (9 - 22) | 47 | 59 | St. Thomas, VI | |
| 11/22/2021 | L | 51 | Creighton (22 - 11) | 64 | 66 | St. Thomas, VI | |
| 11/26/2021 | W | 213 | Alcorn St. (17 - 16) | 62 | 59 | ||
| 12/01/2021 | W | at | 342 | Evansville (6 - 24) | 54 | 52 | |
| 12/04/2021 | W | 340 | Southern Miss (7 - 26) | 66 | 41 | ||
| 12/11/2021 | L | at | 260 | Tulsa (11 - 20) | 65 | 69 | |
| 12/15/2021 | W | 234 | Southeast Missouri St. (14 - 18) | 80 | 55 | ||
| 12/18/2021 | W | Maryville MO ( - ) | 75 | 55 | |||
| 12/22/2021 | L | at | 23 | San Francisco (24 - 9) | 52 | 64 | |
| 12/28/2021 | W | 294 | Grambling St. (12 - 20) | 75 | 64 | ||
| 01/08/2022 | W | at | 243 | Valparaiso (14 - 18) | 63 | 60 | |
| 01/12/2022 | L | at | 57 | Missouri St. (23 - 10) | 76 | 81 | |
| 01/15/2022 | L | 82 | Northern Iowa (19 - 11) | 68 | 69 | ||
| 01/17/2022 | L | 70 | Drake (24 - 10) | 59 | 60 | ||
| 01/19/2022 | W | 297 | Indiana St. (11 - 20) | 63 | 55 | ||
| 01/22/2022 | L | at | 151 | Bradley (17 - 14) | 62 | 70 | |
| 01/25/2022 | L | at | 34 | Loyola Chicago (25 - 7) | 47 | 59 | |
| 01/27/2022 | L | 34 | Loyola Chicago (25 - 7) | 39 | 44 | ||
| 01/30/2022 | W | 243 | Valparaiso (14 - 18) | 77 | 55 | ||
| 02/02/2022 | L | 57 | Missouri St. (23 - 10) | 54 | 69 | ||
| 02/05/2022 | W | at | 258 | Illinois St. (13 - 20) | 75 | 69 | |
| 02/09/2022 | L | at | 82 | Northern Iowa (19 - 11) | 44 | 53 | |
| 02/12/2022 | W | 342 | Evansville (6 - 24) | 69 | 62 | ||
| 02/15/2022 | W | 151 | Bradley (17 - 14) | 65 | 57 | ||
| 02/19/2022 | W | at | 297 | Indiana St. (11 - 20) | 76 | 72 | |
| 02/23/2022 | W | 258 | Illinois St. (13 - 20) | 90 | 69 | ||
| 02/26/2022 | L | at | 70 | Drake (24 - 10) | 60 | 62 | |
| 03/04/2022 | L | at | 70 | Drake (24 - 10) | 52 | 65 | St. Louis, MO |