| Team: | Missouri St. | Rating: | 6.75 | Average Socre: | 77.4545 |
| Conference: | Missouri Valley | ||||
| Wins: | 23 | Losses: | 10 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | 234 | Southeast Missouri St. (14 - 18) | 94 | 99 | ||
| 11/13/2021 | W | 328 | Alabama St. (10 - 21) | 78 | 60 | ||
| 11/17/2021 | W | at | 153 | Sam Houston St. (19 - 14) | 77 | 55 | |
| 11/22/2021 | W | at | 104 | Long Beach St. (20 - 12) | 92 | 66 | Naples, FL |
| 11/23/2021 | L | 184 | East Tennessee St. (15 - 17) | 76 | 77 | Naples, FL | |
| 11/24/2021 | W | 236 | George Washington (12 - 18) | 72 | 54 | Naples, FL | |
| 12/01/2021 | L | at | 258 | Illinois St. (13 - 20) | 74 | 79 | |
| 12/04/2021 | L | 54 | BYU (22 - 10) | 68 | 74 | ||
| 12/08/2021 | W | at | 301 | Little Rock (9 - 19) | 81 | 55 | |
| 12/11/2021 | W | 154 | Oral Roberts (19 - 12) | 69 | 60 | ||
| 12/15/2021 | W | 17 | South Dakota St. (30 - 4) | 75 | 63 | ||
| 12/18/2021 | W | 279 | Central Arkansas (11 - 20) | 106 | 70 | ||
| 12/22/2021 | L | at | 11 | Saint Mary's (25 - 7) | 58 | 75 | |
| 12/30/2021 | W | Evangel ( - ) | 103 | 56 | |||
| 01/02/2022 | W | 70 | Drake (24 - 10) | 61 | 56 | ||
| 01/05/2022 | W | at | 151 | Bradley (17 - 14) | 71 | 69 | |
| 01/08/2022 | L | 82 | Northern Iowa (19 - 11) | 84 | 85 | ||
| 01/12/2022 | W | 183 | Southern Illinois (16 - 15) | 81 | 76 | ||
| 01/15/2022 | W | at | 243 | Valparaiso (14 - 18) | 74 | 57 | |
| 01/19/2022 | W | 258 | Illinois St. (13 - 20) | 88 | 63 | ||
| 01/22/2022 | W | at | 34 | Loyola Chicago (25 - 7) | 79 | 69 | |
| 01/25/2022 | L | at | 297 | Indiana St. (11 - 20) | 72 | 76 | |
| 01/29/2022 | W | 342 | Evansville (6 - 24) | 72 | 58 | ||
| 02/02/2022 | W | at | 183 | Southern Illinois (16 - 15) | 69 | 54 | |
| 02/06/2022 | L | 34 | Loyola Chicago (25 - 7) | 62 | 71 | ||
| 02/09/2022 | W | at | 70 | Drake (24 - 10) | 66 | 62 | |
| 02/12/2022 | W | 243 | Valparaiso (14 - 18) | 84 | 66 | ||
| 02/15/2022 | W | 297 | Indiana St. (11 - 20) | 79 | 70 | ||
| 02/20/2022 | L | at | 82 | Northern Iowa (19 - 11) | 75 | 95 | |
| 02/23/2022 | W | 151 | Bradley (17 - 14) | 83 | 67 | ||
| 02/26/2022 | W | at | 342 | Evansville (6 - 24) | 88 | 79 | |
| 03/04/2022 | W | 243 | Valparaiso (14 - 18) | 67 | 58 | St. Louis, MO | |
| 03/05/2022 | L | 70 | Drake (24 - 10) | 78 | 79 | St. Louis, MO |