| Team: | Illinois St. | Rating: | -3.5161 | Average Socre: | 74.1515 |
| Conference: | Missouri Valley | ||||
| Wins: | 13 | Losses: | 20 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 85 | UNC Wilmington (23 - 9) | 68 | 63 | ||
| 11/12/2021 | L | at | 300 | Eastern Michigan (10 - 21) | 98 | 103 | |
| 11/16/2021 | L | 3 | Murray St. (30 - 2) | 65 | 77 | ||
| 11/20/2021 | W | 324 | Bucknell (9 - 23) | 105 | 100 | ||
| 11/23/2021 | L | at | 50 | Saint Louis (23 - 11) | 76 | 82 | Riviera Maya, Mexico |
| 11/24/2021 | L | 114 | Buffalo (19 - 11) | 90 | 106 | Riviera Maya, Mexico | |
| 11/27/2021 | W | Purdue Northwest ( - ) | 81 | 71 | |||
| 12/01/2021 | W | 57 | Missouri St. (23 - 10) | 79 | 74 | ||
| 12/04/2021 | L | 299 | Jackson St. (11 - 19) | 55 | 61 | ||
| 12/11/2021 | W | at | 327 | Chicago St. (7 - 25) | 81 | 71 | |
| 12/14/2021 | W | Quincy ( - ) | 81 | 63 | |||
| 12/18/2021 | W | 229 | Ball St. (14 - 17) | 85 | 64 | ||
| 12/21/2021 | W | 323 | UTSA (10 - 22) | 81 | 64 | ||
| 12/29/2021 | L | at | 18 | Wisconsin (24 - 7) | 85 | 89 | |
| 01/02/2022 | L | at | 243 | Valparaiso (14 - 18) | 76 | 81 | |
| 01/12/2022 | L | at | 70 | Drake (24 - 10) | 75 | 86 | |
| 01/16/2022 | W | 151 | Bradley (17 - 14) | 74 | 65 | ||
| 01/19/2022 | L | at | 57 | Missouri St. (23 - 10) | 63 | 88 | |
| 01/21/2022 | W | 342 | Evansville (6 - 24) | 94 | 56 | ||
| 01/23/2022 | L | at | 342 | Evansville (6 - 24) | 53 | 56 | |
| 01/26/2022 | L | 70 | Drake (24 - 10) | 88 | 89 | ||
| 01/29/2022 | L | at | 82 | Northern Iowa (19 - 11) | 64 | 79 | |
| 02/02/2022 | L | at | 34 | Loyola Chicago (25 - 7) | 64 | 78 | |
| 02/05/2022 | L | 183 | Southern Illinois (16 - 15) | 69 | 75 | ||
| 02/09/2022 | W | 243 | Valparaiso (14 - 18) | 78 | 75 | ||
| 02/12/2022 | L | at | 297 | Indiana St. (11 - 20) | 57 | 60 | |
| 02/15/2022 | L | 82 | Northern Iowa (19 - 11) | 70 | 72 | ||
| 02/19/2022 | L | at | 151 | Bradley (17 - 14) | 64 | 72 | |
| 02/21/2022 | L | 34 | Loyola Chicago (25 - 7) | 50 | 59 | ||
| 02/23/2022 | L | at | 183 | Southern Illinois (16 - 15) | 69 | 90 | |
| 02/26/2022 | W | 297 | Indiana St. (11 - 20) | 86 | 66 | ||
| 03/03/2022 | W | 297 | Indiana St. (11 - 20) | 58 | 53 | St. Louis, MO | |
| 03/04/2022 | L | at | 82 | Northern Iowa (19 - 11) | 65 | 78 | St. Louis, MO |