| Team: | Southeast Missouri St. | Rating: | -2.7333 | Average Socre: | 75.5625 |
| Conference: | Ohio Valley | ||||
| Wins: | 14 | Losses: | 18 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | at | 57 | Missouri St. (23 - 10) | 99 | 94 | |
| 11/13/2021 | L | 214 | Youngstown St. (18 - 14) | 79 | 97 | ||
| 11/19/2021 | L | 141 | Arkansas St. (18 - 11) | 60 | 72 | ||
| 11/22/2021 | W | Missouri Baptist ( - ) | 71 | 63 | |||
| 11/26/2021 | W | at | 339 | Incarnate Word (7 - 25) | 79 | 76 | |
| 11/27/2021 | L | at | 177 | Portland (18 - 14) | 68 | 74 | San Antonio, TX |
| 11/28/2021 | L | at | 41 | Montana St. (27 - 7) | 68 | 75 | San Antonio, TX |
| 12/04/2021 | W | Webster ( - ) | 76 | 64 | |||
| 12/08/2021 | W | 342 | Evansville (6 - 24) | 75 | 73 | ||
| 12/11/2021 | L | at | 129 | Purdue Fort Wayne (21 - 11) | 65 | 78 | |
| 12/15/2021 | L | at | 183 | Southern Illinois (16 - 15) | 55 | 80 | |
| 12/18/2021 | L | at | 325 | Pepperdine (7 - 25) | 77 | 83 | |
| 12/21/2021 | L | at | 206 | Cal Baptist (18 - 15) | 68 | 84 | |
| 12/30/2021 | L | at | 3 | Murray St. (30 - 2) | 81 | 106 | |
| 01/01/2022 | W | 275 | Austin Peay (12 - 17) | 98 | 79 | ||
| 01/06/2022 | L | at | 33 | Belmont (25 - 7) | 62 | 102 | |
| 01/08/2022 | L | at | 277 | Tennessee St. (14 - 18) | 84 | 95 | |
| 01/20/2022 | W | 277 | Tennessee St. (14 - 18) | 85 | 63 | ||
| 01/22/2022 | W | at | 354 | Eastern Illinois (5 - 26) | 87 | 58 | |
| 01/27/2022 | L | 96 | Morehead St. (23 - 11) | 73 | 74 | ||
| 01/29/2022 | W | 302 | SIU Edwardsville (11 - 21) | 85 | 77 | ||
| 02/03/2022 | L | at | 332 | Tennessee Martin (8 - 22) | 63 | 84 | |
| 02/05/2022 | W | 354 | Eastern Illinois (5 - 26) | 63 | 56 | ||
| 02/07/2022 | W | at | 302 | SIU Edwardsville (11 - 21) | 76 | 47 | |
| 02/10/2022 | L | at | 275 | Austin Peay (12 - 17) | 66 | 74 | |
| 02/12/2022 | L | 33 | Belmont (25 - 7) | 72 | 81 | ||
| 02/17/2022 | L | at | 291 | Tennessee Tech (11 - 21) | 94 | 98 | |
| 02/19/2022 | W | at | 96 | Morehead St. (23 - 11) | 92 | 84 | |
| 02/24/2022 | W | 332 | Tennessee Martin (8 - 22) | 76 | 69 | ||
| 02/26/2022 | L | 3 | Murray St. (30 - 2) | 68 | 70 | ||
| 03/03/2022 | W | 277 | Tennessee St. (14 - 18) | 79 | 55 | Evansville, IN | |
| 03/04/2022 | L | at | 3 | Murray St. (30 - 2) | 74 | 88 | Evansville, IN |