| Team: | Sam Houston St. | Rating: | 2.1333 | Average Socre: | 68.8485 |
| Conference: | WAC | ||||
| Wins: | 19 | Losses: | 14 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | W | LeTourneau ( - ) | 97 | 54 | |||
| 11/12/2021 | L | at | 265 | Nebraska (10 - 22) | 65 | 74 | |
| 11/17/2021 | L | 57 | Missouri St. (23 - 10) | 55 | 77 | ||
| 11/21/2021 | W | 301 | Little Rock (9 - 19) | 77 | 59 | Jacksonville, FL | |
| 11/22/2021 | L | 158 | Boston University (21 - 12) | 59 | 72 | Jacksonville, FL | |
| 11/24/2021 | L | at | 44 | SMU (23 - 8) | 66 | 75 | |
| 11/29/2021 | L | at | 55 | Texas (21 - 11) | 57 | 73 | |
| 12/02/2021 | W | Schreiner ( - ) | 106 | 46 | |||
| 12/11/2021 | L | 323 | UTSA (10 - 22) | 73 | 78 | Houston, TX | |
| 12/14/2021 | L | at | 19 | North Texas (24 - 6) | 55 | 65 | |
| 12/18/2021 | W | Hardin Simmons ( - ) | 103 | 53 | |||
| 12/21/2021 | L | 151 | Bradley (17 - 14) | 61 | 87 | El Paso, TX | |
| 12/22/2021 | W | 241 | North Carolina Central (16 - 15) | 68 | 51 | El Paso, TX | |
| 12/30/2021 | W | 357 | Lamar (2 - 27) | 75 | 64 | ||
| 01/03/2022 | W | 322 | UT Rio Grande Valley (8 - 23) | 86 | 78 | ||
| 01/06/2022 | L | at | 233 | Tarleton St. (14 - 17) | 64 | 75 | |
| 01/08/2022 | W | at | 90 | Abilene Christian (23 - 10) | 65 | 63 | |
| 01/13/2022 | W | at | 357 | Lamar (2 - 27) | 73 | 56 | |
| 01/15/2022 | W | 60 | Stephen F. Austin (22 - 9) | 49 | 41 | ||
| 01/20/2022 | W | 21 | New Mexico St. (26 - 6) | 71 | 46 | ||
| 01/22/2022 | W | 53 | Grand Canyon (23 - 8) | 58 | 56 | ||
| 01/26/2022 | W | at | 206 | Cal Baptist (18 - 15) | 73 | 68 | |
| 01/29/2022 | L | at | 80 | Seattle (23 - 9) | 63 | 78 | |
| 02/03/2022 | W | 232 | Dixie St. (13 - 18) | 77 | 53 | ||
| 02/05/2022 | L | 93 | Utah Valley (20 - 12) | 54 | 57 | ||
| 02/12/2022 | W | at | 327 | Chicago St. (7 - 25) | 72 | 59 | |
| 02/17/2022 | W | 90 | Abilene Christian (23 - 10) | 75 | 71 | ||
| 02/19/2022 | W | at | 322 | UT Rio Grande Valley (8 - 23) | 67 | 61 | |
| 02/24/2022 | L | at | 60 | Stephen F. Austin (22 - 9) | 67 | 69 | |
| 02/26/2022 | L | at | 53 | Grand Canyon (23 - 8) | 41 | 67 | |
| 03/03/2022 | W | 233 | Tarleton St. (14 - 17) | 69 | 50 | ||
| 03/09/2022 | W | 206 | Cal Baptist (18 - 15) | 65 | 35 | Paradise, NV | |
| 03/10/2022 | L | at | 53 | Grand Canyon (23 - 8) | 66 | 71 | Paradise, NV |