| Team: | Louisiana Tech | Rating: | 6.4194 | Average Socre: | 75.2353 |
| Conference: | Conference USA | ||||
| Wins: | 24 | Losses: | 10 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 43 | Alabama (19 - 13) | 64 | 93 | |
| 11/12/2021 | W | 299 | Jackson St. (11 - 19) | 70 | 68 | ||
| 11/15/2021 | W | Jarvis Christian ( - ) | 91 | 61 | |||
| 11/19/2021 | W | at | 335 | Northwestern St. (9 - 23) | 83 | 64 | |
| 11/24/2021 | W | 254 | Louisiana Monroe (13 - 18) | 96 | 74 | ||
| 11/27/2021 | L | at | 249 | N.C. State (11 - 21) | 81 | 90 | |
| 12/01/2021 | W | 187 | Texas Southern (18 - 12) | 87 | 60 | ||
| 12/04/2021 | W | at | 64 | Santa Clara (21 - 11) | 78 | 75 | |
| 12/11/2021 | W | 173 | Louisiana (16 - 15) | 78 | 69 | ||
| 12/14/2021 | W | LSU Shreveport ( - ) | 84 | 70 | |||
| 12/18/2021 | L | at | 39 | LSU (22 - 11) | 57 | 66 | Bossier City, LA |
| 12/22/2021 | W | Crowley's Ridge ( - ) | 99 | 56 | |||
| 12/30/2021 | W | 261 | Marshall (12 - 21) | 79 | 56 | ||
| 01/01/2022 | W | 144 | Western Kentucky (19 - 13) | 74 | 73 | ||
| 01/06/2022 | W | at | 116 | UTEP (19 - 13) | 64 | 52 | |
| 01/08/2022 | W | at | 323 | UTSA (10 - 22) | 79 | 63 | |
| 01/13/2022 | W | 340 | Southern Miss (7 - 26) | 80 | 57 | ||
| 01/16/2022 | W | at | 340 | Southern Miss (7 - 26) | 76 | 62 | |
| 01/22/2022 | L | 24 | UAB (27 - 7) | 76 | 83 | ||
| 01/27/2022 | W | 188 | Rice (16 - 16) | 80 | 63 | ||
| 01/29/2022 | L | 19 | North Texas (24 - 6) | 62 | 63 | ||
| 02/03/2022 | L | at | 168 | Florida Atlantic (19 - 14) | 73 | 83 | |
| 02/05/2022 | W | at | 250 | FIU (15 - 17) | 86 | 82 | |
| 02/10/2022 | W | at | 138 | Charlotte (17 - 14) | 82 | 77 | |
| 02/17/2022 | L | 116 | UTEP (19 - 13) | 60 | 63 | ||
| 02/19/2022 | W | 323 | UTSA (10 - 22) | 95 | 71 | ||
| 02/24/2022 | W | at | 188 | Rice (16 - 16) | 83 | 79 | |
| 02/26/2022 | L | at | 19 | North Texas (24 - 6) | 49 | 56 | |
| 03/02/2022 | W | 221 | Old Dominion (13 - 19) | 67 | 54 | ||
| 03/05/2022 | L | at | 24 | UAB (27 - 7) | 74 | 87 | |
| 03/09/2022 | W | 261 | Marshall (12 - 21) | 77 | 67 | Frisco, TX | |
| 03/10/2022 | W | at | 144 | Western Kentucky (19 - 13) | 59 | 57 | Frisco, TX |
| 03/11/2022 | W | at | 19 | North Texas (24 - 6) | 42 | 36 | Frisco, TX |
| 03/12/2022 | L | at | 24 | UAB (27 - 7) | 73 | 82 | Frisco, TX |