| Team: | Buffalo | Rating: | 3.5714 | Average Socre: | 79.9333 |
| Conference: | Mid American | ||||
| Wins: | 19 | Losses: | 11 | Div 1 Games: | 28 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | L | at | 87 | Michigan (17 - 14) | 76 | 88 | |
| 11/15/2021 | W | at | 19 | North Texas (24 - 6) | 69 | 66 | |
| 11/20/2021 | W | 252 | Rider (14 - 19) | 87 | 65 | ||
| 11/23/2021 | L | 60 | Stephen F. Austin (22 - 9) | 78 | 79 | Riviera Maya, Mexico | |
| 11/24/2021 | W | at | 258 | Illinois St. (13 - 20) | 106 | 90 | Riviera Maya, Mexico |
| 11/29/2021 | W | Point Park ( - ) | 94 | 49 | |||
| 12/04/2021 | L | at | 48 | St. Bonaventure (20 - 9) | 65 | 68 | |
| 12/08/2021 | W | at | 144 | Western Kentucky (19 - 13) | 77 | 67 | |
| 12/11/2021 | W | St. John Fisher ( - ) | 100 | 58 | |||
| 12/18/2021 | L | at | 270 | Canisius (11 - 21) | 64 | 65 | Buffalo, NY |
| 12/29/2021 | L | 276 | Miami OH (14 - 18) | 81 | 91 | ||
| 01/01/2022 | L | at | 74 | Akron (24 - 9) | 76 | 88 | |
| 01/05/2022 | W | 264 | Bowling Green (13 - 18) | 99 | 88 | ||
| 01/11/2022 | W | at | 316 | Western Michigan (8 - 23) | 78 | 64 | |
| 01/14/2022 | W | at | 229 | Ball St. (14 - 17) | 74 | 68 | |
| 01/21/2022 | W | 73 | Kent St. (23 - 10) | 64 | 51 | ||
| 01/25/2022 | L | at | 42 | Toledo (26 - 7) | 75 | 86 | |
| 01/28/2022 | L | 65 | Ohio (24 - 9) | 53 | 74 | ||
| 02/05/2022 | W | at | 310 | Central Michigan (7 - 23) | 74 | 54 | |
| 02/08/2022 | W | 300 | Eastern Michigan (10 - 21) | 102 | 64 | ||
| 02/12/2022 | W | 229 | Ball St. (14 - 17) | 80 | 74 | ||
| 02/15/2022 | W | at | 264 | Bowling Green (13 - 18) | 112 | 85 | |
| 02/17/2022 | W | at | 300 | Eastern Michigan (10 - 21) | 83 | 69 | |
| 02/19/2022 | W | 316 | Western Michigan (8 - 23) | 87 | 73 | ||
| 02/22/2022 | W | at | 276 | Miami OH (14 - 18) | 86 | 84 | |
| 02/24/2022 | W | at | 293 | Northern Illinois (9 - 21) | 79 | 68 | |
| 02/26/2022 | W | 293 | Northern Illinois (9 - 21) | 70 | 60 | ||
| 03/01/2022 | L | 42 | Toledo (26 - 7) | 76 | 92 | ||
| 03/04/2022 | L | at | 73 | Kent St. (23 - 10) | 65 | 70 | |
| 03/10/2022 | L | at | 74 | Akron (24 - 9) | 68 | 70 | Cleveland, OH |