| Team: | Southern Miss | Rating: | -9.0645 | Average Socre: | 64.4242 |
| Conference: | Conference USA | ||||
| Wins: | 7 | Losses: | 26 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | William Carey ( - ) | 81 | 67 | |||
| 11/12/2021 | L | 173 | Louisiana (16 - 15) | 45 | 66 | ||
| 11/15/2021 | L | at | 72 | TCU (20 - 12) | 51 | 83 | |
| 11/21/2021 | W | 357 | Lamar (2 - 27) | 82 | 75 | ||
| 11/24/2021 | W | at | 85 | UNC Wilmington (23 - 9) | 80 | 66 | Missoula, MT |
| 11/25/2021 | W | 255 | UC San Diego (13 - 16) | 56 | 55 | Missoula, MT | |
| 11/26/2021 | L | at | 202 | Montana (18 - 14) | 62 | 74 | |
| 12/01/2021 | L | at | 145 | South Alabama (19 - 11) | 55 | 85 | |
| 12/04/2021 | L | at | 183 | Southern Illinois (16 - 15) | 41 | 66 | |
| 12/14/2021 | L | 137 | Jacksonville (21 - 10) | 51 | 62 | ||
| 12/18/2021 | L | at | 254 | Louisiana Monroe (13 - 18) | 65 | 74 | |
| 12/21/2021 | L | at | 186 | East Carolina (15 - 15) | 67 | 68 | |
| 01/06/2022 | W | at | 323 | UTSA (10 - 22) | 74 | 73 | |
| 01/08/2022 | L | at | 116 | UTEP (19 - 13) | 54 | 87 | |
| 01/13/2022 | L | at | 67 | Louisiana Tech (24 - 10) | 57 | 80 | |
| 01/16/2022 | L | 67 | Louisiana Tech (24 - 10) | 62 | 76 | ||
| 01/19/2022 | W | Southeastern Baptist ( - ) | 100 | 50 | |||
| 01/22/2022 | L | at | 62 | Middle Tennessee (23 - 10) | 60 | 74 | |
| 01/27/2022 | L | 19 | North Texas (24 - 6) | 54 | 63 | ||
| 01/29/2022 | L | 188 | Rice (16 - 16) | 62 | 76 | ||
| 02/03/2022 | L | at | 250 | FIU (15 - 17) | 67 | 77 | |
| 02/05/2022 | L | at | 168 | Florida Atlantic (19 - 14) | 57 | 84 | |
| 02/10/2022 | L | at | 24 | UAB (27 - 7) | 63 | 84 | |
| 02/14/2022 | L | 144 | Western Kentucky (19 - 13) | 77 | 87 | ||
| 02/17/2022 | L | 323 | UTSA (10 - 22) | 79 | 98 | ||
| 02/19/2022 | L | 116 | UTEP (19 - 13) | 70 | 84 | ||
| 02/21/2022 | L | 261 | Marshall (12 - 21) | 60 | 74 | ||
| 02/24/2022 | L | at | 19 | North Texas (24 - 6) | 61 | 85 | |
| 02/26/2022 | L | at | 188 | Rice (16 - 16) | 72 | 77 | |
| 03/02/2022 | L | 24 | UAB (27 - 7) | 68 | 81 | ||
| 03/05/2022 | L | 138 | Charlotte (17 - 14) | 67 | 70 | ||
| 03/08/2022 | W | at | 323 | UTSA (10 - 22) | 67 | 64 | Frisco, TX |
| 03/09/2022 | L | at | 168 | Florida Atlantic (19 - 14) | 59 | 86 | Frisco, TX |