| Team: | Creighton | Rating: | 7.303 | Average Socre: | 69.0303 |
| Conference: | Big East | ||||
| Wins: | 22 | Losses: | 11 | Div 1 Games: | 33 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 347 | Arkansas Pine Bluff (7 - 24) | 90 | 77 | ||
| 11/11/2021 | W | 274 | Kennesaw St. (13 - 18) | 51 | 44 | ||
| 11/16/2021 | W | at | 265 | Nebraska (10 - 22) | 77 | 69 | |
| 11/19/2021 | W | 224 | Brown (13 - 16) | 78 | 57 | St. Thomas, VI | |
| 11/21/2021 | L | 9 | Colorado St. (25 - 5) | 81 | 95 | St. Thomas, VI | |
| 11/22/2021 | W | at | 183 | Southern Illinois (16 - 15) | 66 | 64 | St. Thomas, VI |
| 11/27/2021 | W | 302 | SIU Edwardsville (11 - 21) | 70 | 65 | ||
| 11/30/2021 | W | 88 | North Dakota St. (23 - 10) | 80 | 55 | ||
| 12/04/2021 | L | 81 | Iowa St. (20 - 12) | 58 | 64 | ||
| 12/11/2021 | W | 54 | BYU (22 - 10) | 83 | 71 | Sioux Falls, SD | |
| 12/14/2021 | L | 161 | Arizona St. (14 - 17) | 57 | 58 | ||
| 12/17/2021 | W | 14 | Villanova (26 - 7) | 79 | 59 | ||
| 01/01/2022 | W | at | 78 | Marquette (19 - 12) | 75 | 69 | |
| 01/05/2022 | L | at | 14 | Villanova (26 - 7) | 41 | 75 | |
| 01/15/2022 | L | at | 83 | Xavier (18 - 13) | 73 | 80 | |
| 01/19/2022 | W | 143 | St. John's (17 - 15) | 87 | 64 | ||
| 01/22/2022 | W | 172 | DePaul (15 - 16) | 60 | 47 | ||
| 01/26/2022 | L | at | 205 | Butler (14 - 19) | 55 | 72 | |
| 01/29/2022 | L | 83 | Xavier (18 - 13) | 64 | 74 | ||
| 02/01/2022 | W | at | 40 | Connecticut (23 - 9) | 59 | 55 | |
| 02/04/2022 | L | at | 59 | Seton Hall (21 - 10) | 55 | 74 | |
| 02/08/2022 | W | 205 | Butler (14 - 19) | 54 | 52 | ||
| 02/12/2022 | W | at | 303 | Georgetown (6 - 25) | 80 | 66 | |
| 02/14/2022 | W | 303 | Georgetown (6 - 25) | 88 | 77 | ||
| 02/17/2022 | W | at | 172 | DePaul (15 - 16) | 71 | 59 | |
| 02/20/2022 | W | 78 | Marquette (19 - 12) | 83 | 82 | ||
| 02/23/2022 | W | at | 143 | St. John's (17 - 15) | 81 | 78 | |
| 02/26/2022 | L | at | 10 | Providence (25 - 5) | 51 | 72 | |
| 03/02/2022 | W | 40 | Connecticut (23 - 9) | 64 | 62 | ||
| 03/05/2022 | L | 59 | Seton Hall (21 - 10) | 60 | 65 | ||
| 03/10/2022 | W | 78 | Marquette (19 - 12) | 74 | 63 | New York, NY | |
| 03/11/2022 | W | at | 10 | Providence (25 - 5) | 85 | 58 | New York, NY |
| 03/12/2022 | L | at | 14 | Villanova (26 - 7) | 48 | 54 | New York, NY |