| Team: | Saint Joseph's | Rating: | -3.1 | Average Socre: | 67.6 |
| Conference: | Atlantic 10 | ||||
| Wins: | 11 | Losses: | 19 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 280 | Maryland Eastern Shore (11 - 15) | 69 | 67 | ||
| 11/13/2021 | W | 227 | Mount St. Mary's (14 - 16) | 80 | 60 | ||
| 11/17/2021 | L | 185 | Drexel (15 - 14) | 75 | 78 | ||
| 11/20/2021 | L | 94 | Monmouth (21 - 13) | 75 | 87 | ||
| 11/25/2021 | L | at | 32 | USC (26 - 7) | 55 | 70 | Anaheim, CA |
| 11/26/2021 | W | at | 303 | Georgetown (6 - 25) | 77 | 74 | Anaheim, CA |
| 12/01/2021 | W | 267 | Binghamton (12 - 17) | 79 | 57 | ||
| 12/04/2021 | L | at | 14 | Villanova (26 - 7) | 52 | 81 | |
| 12/08/2021 | W | 220 | Penn (12 - 16) | 78 | 71 | ||
| 12/11/2021 | W | 124 | Temple (17 - 12) | 68 | 49 | ||
| 12/18/2021 | L | at | 151 | Bradley (17 - 14) | 73 | 77 | |
| 12/30/2021 | W | at | 58 | Richmond (23 - 12) | 83 | 56 | |
| 01/05/2022 | L | 28 | Davidson (27 - 6) | 73 | 88 | ||
| 01/12/2022 | L | at | 196 | Rhode Island (15 - 16) | 64 | 75 | |
| 01/17/2022 | L | 271 | La Salle (11 - 19) | 64 | 75 | ||
| 01/19/2022 | W | 236 | George Washington (12 - 18) | 72 | 61 | ||
| 01/22/2022 | L | at | 35 | VCU (21 - 9) | 54 | 70 | |
| 01/24/2022 | L | at | 191 | George Mason (14 - 16) | 71 | 77 | |
| 01/26/2022 | W | 334 | Duquesne (6 - 24) | 72 | 61 | ||
| 01/29/2022 | L | at | 48 | St. Bonaventure (20 - 9) | 69 | 80 | |
| 02/05/2022 | W | 190 | Fordham (16 - 16) | 72 | 69 | ||
| 02/09/2022 | L | at | 28 | Davidson (27 - 6) | 67 | 73 | |
| 02/12/2022 | L | at | 195 | Massachusetts (15 - 17) | 67 | 69 | |
| 02/16/2022 | L | 191 | George Mason (14 - 16) | 70 | 75 | ||
| 02/19/2022 | L | 52 | Dayton (23 - 10) | 62 | 74 | ||
| 02/22/2022 | L | at | 50 | Saint Louis (23 - 11) | 61 | 72 | |
| 02/26/2022 | L | 48 | St. Bonaventure (20 - 9) | 52 | 54 | ||
| 03/02/2022 | L | at | 271 | La Salle (11 - 19) | 48 | 49 | |
| 03/05/2022 | W | 196 | Rhode Island (15 - 16) | 70 | 60 | ||
| 03/09/2022 | L | at | 271 | La Salle (11 - 19) | 56 | 63 | Washington, DC |