| Team: | Maryland Eastern Shore | Rating: | -4.8696 | Average Socre: | 66.7692 |
| Conference: | Mid Eastern | ||||
| Wins: | 11 | Losses: | 15 | Div 1 Games: | 23 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 246 | Saint Joseph's (11 - 19) | 67 | 69 | |
| 11/10/2021 | L | at | 124 | Temple (17 - 12) | 49 | 72 | |
| 11/13/2021 | W | Bryn Athyn ( - ) | 91 | 42 | |||
| 11/19/2021 | W | at | 190 | Fordham (16 - 16) | 75 | 73 | |
| 11/24/2021 | L | at | 198 | Campbell (16 - 13) | 55 | 66 | |
| 11/27/2021 | L | at | 107 | Liberty (22 - 11) | 61 | 73 | |
| 11/30/2021 | L | at | 40 | Connecticut (23 - 9) | 63 | 72 | |
| 12/04/2021 | W | at | 272 | Lehigh (13 - 19) | 81 | 75 | |
| 12/08/2021 | W | Clarks Summit ( - ) | 102 | 58 | |||
| 12/11/2021 | W | St. Mary's MD ( - ) | 79 | 43 | |||
| 12/20/2021 | L | at | 138 | Charlotte (17 - 14) | 54 | 70 | |
| 01/17/2022 | L | 86 | Norfolk St. (24 - 6) | 58 | 72 | ||
| 01/22/2022 | L | 268 | South Carolina St. (15 - 16) | 60 | 69 | ||
| 01/24/2022 | L | 241 | North Carolina Central (16 - 15) | 63 | 75 | ||
| 01/29/2022 | W | at | 296 | Coppin St. (9 - 23) | 64 | 61 | |
| 01/31/2022 | W | 256 | Morgan St. (13 - 14) | 79 | 72 | ||
| 02/05/2022 | L | at | 225 | Howard (16 - 13) | 64 | 72 | |
| 02/09/2022 | W | at | 355 | Delaware St. (2 - 26) | 58 | 50 | |
| 02/12/2022 | L | at | 86 | Norfolk St. (24 - 6) | 63 | 70 | |
| 02/14/2022 | L | 225 | Howard (16 - 13) | 71 | 77 | ||
| 02/19/2022 | L | at | 268 | South Carolina St. (15 - 16) | 63 | 70 | |
| 02/21/2022 | W | at | 241 | North Carolina Central (16 - 15) | 79 | 66 | |
| 02/26/2022 | W | 296 | Coppin St. (9 - 23) | 70 | 50 | ||
| 02/28/2022 | L | at | 256 | Morgan St. (13 - 14) | 48 | 82 | |
| 03/03/2022 | W | 355 | Delaware St. (2 - 26) | 63 | 59 | ||
| 03/10/2022 | L | at | 241 | North Carolina Central (16 - 15) | 56 | 68 | Norfolk, VA |