| Team: | Duquesne | Rating: | -8.1667 | Average Socre: | 65.2 |
| Conference: | Atlantic 10 | ||||
| Wins: | 6 | Losses: | 24 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 252 | Rider (14 - 19) | 73 | 61 | ||
| 11/13/2021 | L | 89 | Hofstra (21 - 11) | 63 | 73 | ||
| 11/15/2021 | L | 131 | Weber St. (21 - 12) | 59 | 63 | ||
| 11/19/2021 | L | 281 | Northeastern (9 - 22) | 55 | 71 | St. Thomas, VI | |
| 11/20/2021 | L | at | 79 | Colorado (21 - 11) | 76 | 84 | St. Thomas, VI |
| 11/22/2021 | W | 151 | Bradley (17 - 14) | 78 | 70 | St. Thomas, VI | |
| 11/28/2021 | W | 318 | American (10 - 22) | 88 | 79 | ||
| 12/01/2021 | L | 264 | Bowling Green (13 - 18) | 70 | 78 | ||
| 12/04/2021 | L | at | 261 | Marshall (12 - 21) | 71 | 72 | |
| 12/07/2021 | L | at | 172 | DePaul (15 - 16) | 67 | 87 | |
| 12/11/2021 | W | 204 | New Hampshire (15 - 13) | 64 | 62 | ||
| 12/19/2021 | W | 146 | UC Irvine (15 - 10) | 76 | 54 | Akron, OH | |
| 01/08/2022 | W | at | 195 | Massachusetts (15 - 17) | 78 | 74 | |
| 01/12/2022 | L | at | 190 | Fordham (16 - 16) | 71 | 72 | |
| 01/15/2022 | L | 52 | Dayton (23 - 10) | 52 | 72 | ||
| 01/21/2022 | L | 48 | St. Bonaventure (20 - 9) | 56 | 64 | ||
| 01/26/2022 | L | at | 246 | Saint Joseph's (11 - 19) | 61 | 72 | |
| 01/29/2022 | L | 50 | Saint Louis (23 - 11) | 53 | 77 | ||
| 02/01/2022 | L | 58 | Richmond (23 - 12) | 57 | 74 | ||
| 02/05/2022 | L | at | 35 | VCU (21 - 9) | 62 | 71 | |
| 02/09/2022 | L | at | 52 | Dayton (23 - 10) | 54 | 75 | |
| 02/12/2022 | L | 190 | Fordham (16 - 16) | 54 | 65 | ||
| 02/14/2022 | L | at | 28 | Davidson (27 - 6) | 61 | 72 | |
| 02/16/2022 | L | 236 | George Washington (12 - 18) | 52 | 73 | ||
| 02/19/2022 | L | at | 48 | St. Bonaventure (20 - 9) | 55 | 81 | |
| 02/23/2022 | L | 28 | Davidson (27 - 6) | 50 | 74 | ||
| 02/26/2022 | L | at | 196 | Rhode Island (15 - 16) | 54 | 70 | |
| 03/02/2022 | L | at | 236 | George Washington (12 - 18) | 93 | 98 | |
| 03/05/2022 | L | 271 | La Salle (11 - 19) | 76 | 85 | ||
| 03/09/2022 | L | at | 196 | Rhode Island (15 - 16) | 77 | 79 | Washington, DC |