| Team: | La Salle | Rating: | -4.2 | Average Socre: | 67.5 |
| Conference: | Atlantic 10 | ||||
| Wins: | 11 | Losses: | 19 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | 319 | Sacred Heart (10 - 20) | 81 | 86 | ||
| 11/13/2021 | W | 253 | Albany (13 - 18) | 67 | 64 | ||
| 11/17/2021 | L | at | 91 | Delaware (22 - 12) | 82 | 85 | |
| 11/20/2021 | W | 235 | Army (15 - 16) | 61 | 58 | ||
| 11/28/2021 | L | 14 | Villanova (26 - 7) | 46 | 72 | ||
| 12/01/2021 | L | at | 124 | Temple (17 - 12) | 57 | 73 | |
| 12/04/2021 | W | 341 | Holy Cross (9 - 22) | 84 | 65 | ||
| 12/07/2021 | W | 350 | Fairleigh Dickinson (4 - 22) | 81 | 55 | ||
| 12/11/2021 | W | 220 | Penn (12 - 16) | 76 | 74 | ||
| 12/18/2021 | L | at | 324 | Bucknell (9 - 23) | 70 | 82 | |
| 12/30/2021 | L | 190 | Fordham (16 - 16) | 61 | 69 | ||
| 01/08/2022 | L | 35 | VCU (21 - 9) | 66 | 85 | ||
| 01/11/2022 | L | 48 | St. Bonaventure (20 - 9) | 76 | 80 | ||
| 01/17/2022 | W | at | 246 | Saint Joseph's (11 - 19) | 75 | 64 | |
| 01/19/2022 | L | at | 196 | Rhode Island (15 - 16) | 54 | 56 | |
| 01/22/2022 | L | 58 | Richmond (23 - 12) | 56 | 64 | ||
| 01/26/2022 | L | 195 | Massachusetts (15 - 17) | 71 | 77 | ||
| 01/29/2022 | L | at | 28 | Davidson (27 - 6) | 69 | 77 | |
| 02/02/2022 | L | at | 236 | George Washington (12 - 18) | 87 | 89 | |
| 02/05/2022 | W | 191 | George Mason (14 - 16) | 83 | 78 | ||
| 02/08/2022 | L | 50 | Saint Louis (23 - 11) | 57 | 75 | ||
| 02/12/2022 | L | at | 58 | Richmond (23 - 12) | 63 | 77 | |
| 02/16/2022 | L | at | 50 | Saint Louis (23 - 11) | 64 | 90 | |
| 02/19/2022 | L | at | 195 | Massachusetts (15 - 17) | 74 | 80 | |
| 02/23/2022 | L | at | 190 | Fordham (16 - 16) | 54 | 60 | |
| 02/26/2022 | W | 52 | Dayton (23 - 10) | 62 | 60 | ||
| 03/02/2022 | W | 246 | Saint Joseph's (11 - 19) | 49 | 48 | ||
| 03/05/2022 | W | at | 334 | Duquesne (6 - 24) | 85 | 76 | |
| 03/09/2022 | W | 246 | Saint Joseph's (11 - 19) | 63 | 56 | Washington, DC | |
| 03/10/2022 | L | at | 50 | Saint Louis (23 - 11) | 51 | 71 | Washington, DC |