| Team: | Villanova | Rating: | 11.5455 | Average Socre: | 72.6364 |
| Conference: | Big East | ||||
| Wins: | 26 | Losses: | 7 | Div 1 Games: | 33 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 227 | Mount St. Mary's (14 - 16) | 91 | 51 | ||
| 11/12/2021 | L | at | 16 | UCLA (25 - 7) | 77 | 86 | |
| 11/16/2021 | W | 225 | Howard (16 - 13) | 100 | 81 | ||
| 11/20/2021 | W | at | 6 | Tennessee (26 - 7) | 71 | 53 | Uncasville, CT |
| 11/21/2021 | L | at | 15 | Purdue (27 - 7) | 74 | 80 | Uncasville, CT |
| 11/28/2021 | W | at | 271 | La Salle (11 - 19) | 72 | 46 | |
| 12/01/2021 | W | at | 220 | Penn (12 - 16) | 71 | 56 | |
| 12/04/2021 | W | 246 | Saint Joseph's (11 - 19) | 81 | 52 | ||
| 12/07/2021 | W | at | 164 | Syracuse (16 - 17) | 67 | 53 | New York, NY |
| 12/12/2021 | L | at | 12 | Baylor (26 - 6) | 36 | 57 | |
| 12/17/2021 | L | at | 51 | Creighton (22 - 11) | 59 | 79 | |
| 12/21/2021 | W | 83 | Xavier (18 - 13) | 71 | 58 | ||
| 01/01/2022 | W | at | 59 | Seton Hall (21 - 10) | 73 | 67 | |
| 01/05/2022 | W | 51 | Creighton (22 - 11) | 75 | 41 | ||
| 01/08/2022 | W | at | 172 | DePaul (15 - 16) | 79 | 64 | |
| 01/12/2022 | W | at | 83 | Xavier (18 - 13) | 64 | 60 | |
| 01/16/2022 | W | 205 | Butler (14 - 19) | 82 | 42 | ||
| 01/19/2022 | L | 78 | Marquette (19 - 12) | 54 | 57 | ||
| 01/22/2022 | W | at | 303 | Georgetown (6 - 25) | 85 | 74 | |
| 01/25/2022 | W | 172 | DePaul (15 - 16) | 67 | 43 | ||
| 01/29/2022 | W | 143 | St. John's (17 - 15) | 73 | 62 | ||
| 02/02/2022 | L | at | 78 | Marquette (19 - 12) | 73 | 83 | |
| 02/05/2022 | W | 40 | Connecticut (23 - 9) | 85 | 74 | ||
| 02/08/2022 | W | at | 143 | St. John's (17 - 15) | 75 | 69 | |
| 02/12/2022 | W | 59 | Seton Hall (21 - 10) | 73 | 67 | ||
| 02/15/2022 | W | at | 10 | Providence (25 - 5) | 89 | 84 | |
| 02/19/2022 | W | 303 | Georgetown (6 - 25) | 74 | 66 | ||
| 02/22/2022 | L | at | 40 | Connecticut (23 - 9) | 69 | 71 | |
| 03/01/2022 | W | 10 | Providence (25 - 5) | 76 | 74 | ||
| 03/05/2022 | W | at | 205 | Butler (14 - 19) | 78 | 59 | |
| 03/10/2022 | W | at | 143 | St. John's (17 - 15) | 66 | 65 | New York, NY |
| 03/11/2022 | W | 40 | Connecticut (23 - 9) | 63 | 60 | New York, NY | |
| 03/12/2022 | W | 51 | Creighton (22 - 11) | 54 | 48 | New York, NY |