| Team: | SIU Edwardsville | Rating: | -6.3333 | Average Socre: | 67.5313 |
| Conference: | Ohio Valley | ||||
| Wins: | 11 | Losses: | 21 | Div 1 Games: | 30 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | L | at | 78 | Marquette (19 - 12) | 77 | 88 | |
| 11/12/2021 | L | at | 327 | Chicago St. (7 - 25) | 56 | 67 | |
| 11/15/2021 | W | Knox ( - ) | 75 | 37 | |||
| 11/19/2021 | L | at | 211 | Niagara (14 - 16) | 60 | 70 | Youngstown, OH |
| 11/20/2021 | W | at | 214 | Youngstown St. (18 - 14) | 69 | 66 | |
| 11/21/2021 | L | 315 | St. Thomas (10 - 20) | 73 | 86 | Youngstown, OH | |
| 11/27/2021 | L | at | 51 | Creighton (22 - 11) | 65 | 70 | |
| 11/30/2021 | W | at | 343 | Nebraska Omaha (5 - 25) | 75 | 65 | |
| 12/04/2021 | L | at | 151 | Bradley (17 - 14) | 55 | 80 | |
| 12/08/2021 | W | 129 | Purdue Fort Wayne (21 - 11) | 80 | 59 | ||
| 12/12/2021 | W | 169 | UMKC (19 - 12) | 60 | 56 | ||
| 12/19/2021 | W | William Woods ( - ) | 84 | 29 | |||
| 12/21/2021 | L | at | 145 | South Alabama (19 - 11) | 69 | 84 | |
| 01/08/2022 | L | 3 | Murray St. (30 - 2) | 69 | 74 | ||
| 01/13/2022 | W | at | 354 | Eastern Illinois (5 - 26) | 66 | 53 | |
| 01/17/2022 | L | 33 | Belmont (25 - 7) | 64 | 80 | ||
| 01/20/2022 | L | at | 291 | Tennessee Tech (11 - 21) | 76 | 94 | |
| 01/22/2022 | L | at | 96 | Morehead St. (23 - 11) | 74 | 77 | |
| 01/24/2022 | L | at | 332 | Tennessee Martin (8 - 22) | 70 | 76 | |
| 01/27/2022 | L | 277 | Tennessee St. (14 - 18) | 70 | 75 | ||
| 01/29/2022 | L | at | 234 | Southeast Missouri St. (14 - 18) | 77 | 85 | |
| 01/31/2022 | L | at | 275 | Austin Peay (12 - 17) | 63 | 68 | |
| 02/05/2022 | L | at | 3 | Murray St. (30 - 2) | 59 | 79 | |
| 02/07/2022 | L | 234 | Southeast Missouri St. (14 - 18) | 47 | 76 | ||
| 02/10/2022 | W | 332 | Tennessee Martin (8 - 22) | 71 | 63 | ||
| 02/12/2022 | W | 291 | Tennessee Tech (11 - 21) | 61 | 60 | ||
| 02/17/2022 | L | at | 277 | Tennessee St. (14 - 18) | 65 | 81 | |
| 02/19/2022 | L | at | 33 | Belmont (25 - 7) | 62 | 73 | |
| 02/21/2022 | W | 354 | Eastern Illinois (5 - 26) | 66 | 52 | ||
| 02/24/2022 | L | 275 | Austin Peay (12 - 17) | 64 | 68 | ||
| 02/26/2022 | W | 96 | Morehead St. (23 - 11) | 77 | 70 | ||
| 03/02/2022 | L | at | 277 | Tennessee St. (14 - 18) | 62 | 77 | Evansville, IN |