| Team: | Penn St. | Rating: | 0.6774 | Average Socre: | 64.6129 |
| Conference: | Big Ten | ||||
| Wins: | 14 | Losses: | 17 | Div 1 Games: | 31 |
| Date | Rnk | Team | Location | ||||
| 11/10/2021 | W | 214 | Youngstown St. (18 - 14) | 75 | 59 | ||
| 11/15/2021 | L | at | 195 | Massachusetts (15 - 17) | 56 | 81 | |
| 11/18/2021 | W | 326 | St. Francis NY (10 - 20) | 74 | 59 | ||
| 11/22/2021 | W | 178 | Cornell (15 - 11) | 85 | 74 | ||
| 11/26/2021 | L | 39 | LSU (22 - 11) | 63 | 68 | Niceville, FL | |
| 11/27/2021 | W | at | 344 | Oregon St. (3 - 28) | 60 | 45 | Niceville, FL |
| 12/01/2021 | L | 46 | Miami FL (23 - 10) | 58 | 63 | ||
| 12/05/2021 | L | 76 | Ohio St. (19 - 11) | 64 | 76 | ||
| 12/08/2021 | W | 75 | Wagner (21 - 6) | 74 | 54 | ||
| 12/11/2021 | L | at | 49 | Michigan St. (22 - 12) | 64 | 80 | |
| 01/02/2022 | W | 92 | Indiana (20 - 13) | 61 | 58 | ||
| 01/05/2022 | W | at | 193 | Northwestern (15 - 16) | 74 | 70 | |
| 01/08/2022 | L | 15 | Purdue (27 - 7) | 67 | 74 | ||
| 01/11/2022 | W | 109 | Rutgers (18 - 13) | 66 | 49 | ||
| 01/16/2022 | L | at | 76 | Ohio St. (19 - 11) | 56 | 61 | |
| 01/22/2022 | L | at | 30 | Iowa (26 - 9) | 51 | 68 | |
| 01/26/2022 | L | at | 92 | Indiana (20 - 13) | 57 | 74 | |
| 01/31/2022 | W | 30 | Iowa (26 - 9) | 90 | 86 | ||
| 02/05/2022 | L | at | 18 | Wisconsin (24 - 7) | 49 | 51 | |
| 02/08/2022 | L | 87 | Michigan (17 - 14) | 57 | 58 | ||
| 02/12/2022 | L | at | 179 | Minnesota (13 - 17) | 70 | 76 | |
| 02/15/2022 | W | 49 | Michigan St. (22 - 12) | 62 | 58 | ||
| 02/17/2022 | W | 179 | Minnesota (13 - 17) | 67 | 46 | ||
| 02/21/2022 | L | at | 163 | Maryland (15 - 17) | 61 | 67 | |
| 02/25/2022 | W | 193 | Northwestern (15 - 16) | 67 | 60 | ||
| 02/27/2022 | L | 265 | Nebraska (10 - 22) | 70 | 93 | ||
| 03/03/2022 | L | at | 38 | Illinois (22 - 9) | 55 | 60 | |
| 03/06/2022 | L | at | 109 | Rutgers (18 - 13) | 58 | 59 | |
| 03/09/2022 | W | 179 | Minnesota (13 - 17) | 60 | 51 | Indianapolis, IN | |
| 03/10/2022 | W | at | 76 | Ohio St. (19 - 11) | 71 | 68 | Indianapolis, IN |
| 03/11/2022 | L | at | 15 | Purdue (27 - 7) | 61 | 69 | Indianapolis, IN |