| Team: | Samford | Rating: | 4.0345 | Average Socre: | 74.6875 |
| Conference: | Southern | ||||
| Wins: | 21 | Losses: | 11 | Div 1 Games: | 29 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | Maryville TN ( - ) | 99 | 78 | |||
| 11/11/2021 | W | Spring Hill ( - ) | 86 | 69 | |||
| 11/15/2021 | L | at | 23 | San Francisco (24 - 9) | 55 | 77 | |
| 11/18/2021 | W | at | 344 | Oregon St. (3 - 28) | 78 | 77 | |
| 11/26/2021 | W | at | 289 | North Carolina A&T (12 - 20) | 77 | 75 | Niceville, FL |
| 11/27/2021 | W | 314 | McNeese St. (11 - 22) | 83 | 75 | Niceville, FL | |
| 11/30/2021 | W | Mississippi College ( - ) | 83 | 58 | |||
| 12/05/2021 | L | 33 | Belmont (25 - 7) | 73 | 85 | ||
| 12/08/2021 | W | at | 328 | Alabama St. (10 - 21) | 74 | 64 | |
| 12/11/2021 | W | 292 | Alabama A&M (12 - 18) | 52 | 50 | ||
| 12/18/2021 | W | 274 | Kennesaw St. (13 - 18) | 85 | 84 | ||
| 12/21/2021 | W | at | 209 | Mississippi (13 - 19) | 75 | 73 | |
| 12/29/2021 | L | at | 77 | Furman (22 - 12) | 49 | 81 | |
| 01/05/2022 | L | at | 189 | Mercer (16 - 17) | 80 | 83 | |
| 01/08/2022 | W | 273 | Western Carolina (11 - 21) | 85 | 60 | ||
| 01/12/2022 | L | at | 142 | Wofford (19 - 13) | 64 | 87 | |
| 01/15/2022 | L | 184 | East Tennessee St. (15 - 17) | 85 | 88 | ||
| 01/20/2022 | L | at | 181 | VMI (16 - 15) | 80 | 99 | |
| 01/22/2022 | L | at | 149 | UNC Greensboro (17 - 14) | 58 | 61 | |
| 01/26/2022 | W | 189 | Mercer (16 - 17) | 75 | 61 | ||
| 01/29/2022 | W | at | 273 | Western Carolina (11 - 21) | 74 | 64 | |
| 02/02/2022 | W | 22 | Chattanooga (27 - 7) | 80 | 72 | ||
| 02/05/2022 | L | at | 244 | The Citadel (13 - 18) | 93 | 107 | |
| 02/09/2022 | W | 142 | Wofford (19 - 13) | 65 | 60 | ||
| 02/12/2022 | W | at | 184 | East Tennessee St. (15 - 17) | 77 | 73 | |
| 02/17/2022 | W | 181 | VMI (16 - 15) | 100 | 99 | ||
| 02/19/2022 | W | 149 | UNC Greensboro (17 - 14) | 55 | 49 | ||
| 02/21/2022 | W | 244 | The Citadel (13 - 18) | 76 | 74 | ||
| 02/23/2022 | W | 77 | Furman (22 - 12) | 83 | 75 | ||
| 02/26/2022 | L | at | 22 | Chattanooga (27 - 7) | 57 | 70 | |
| 03/05/2022 | W | 149 | UNC Greensboro (17 - 14) | 66 | 64 | Asheville, NC | |
| 03/06/2022 | L | at | 77 | Furman (22 - 12) | 68 | 71 | Asheville, NC |