| Team: | Santa Clara | Rating: | 6.4688 | Average Socre: | 78.125 |
| Conference: | West Coast | ||||
| Wins: | 21 | Losses: | 11 | Div 1 Games: | 32 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | 119 | Cal St. Fullerton (21 - 10) | 84 | 77 | ||
| 11/12/2021 | W | 147 | Stanford (16 - 16) | 88 | 72 | ||
| 11/16/2021 | W | 197 | Nevada (13 - 18) | 96 | 74 | ||
| 11/19/2021 | W | 331 | Cal Poly (7 - 21) | 87 | 57 | ||
| 11/22/2021 | W | at | 72 | TCU (20 - 12) | 85 | 66 | San Juan Capistrano, CA |
| 11/24/2021 | L | 135 | Fresno St. (19 - 13) | 52 | 59 | San Juan Capistrano, CA | |
| 11/27/2021 | L | 146 | UC Irvine (15 - 10) | 64 | 69 | ||
| 11/30/2021 | W | 165 | Hawaii (17 - 11) | 70 | 58 | ||
| 12/04/2021 | L | 67 | Louisiana Tech (24 - 10) | 75 | 78 | ||
| 12/07/2021 | W | 227 | Mount St. Mary's (14 - 16) | 88 | 77 | ||
| 12/11/2021 | L | at | 237 | California (12 - 20) | 60 | 72 | |
| 12/14/2021 | L | at | 20 | Boise St. (27 - 7) | 60 | 72 | |
| 12/17/2021 | W | 278 | Florida A&M (13 - 17) | 80 | 66 | ||
| 12/19/2021 | W | 202 | Montana (18 - 14) | 79 | 64 | ||
| 12/21/2021 | W | at | 307 | San Jose St. (8 - 23) | 79 | 57 | |
| 01/12/2022 | W | at | 333 | Pacific (8 - 22) | 84 | 70 | |
| 01/15/2022 | L | 1 | Gonzaga (26 - 3) | 83 | 115 | ||
| 01/20/2022 | L | at | 11 | Saint Mary's (25 - 7) | 65 | 73 | |
| 01/24/2022 | W | 219 | San Diego (15 - 16) | 78 | 74 | ||
| 01/27/2022 | W | 54 | BYU (22 - 10) | 77 | 76 | ||
| 01/29/2022 | L | at | 23 | San Francisco (24 - 9) | 85 | 88 | |
| 01/31/2022 | W | 333 | Pacific (8 - 22) | 81 | 59 | ||
| 02/03/2022 | W | 226 | Loyola Marymount (11 - 18) | 79 | 60 | ||
| 02/05/2022 | W | at | 219 | San Diego (15 - 16) | 79 | 66 | |
| 02/08/2022 | W | 11 | Saint Mary's (25 - 7) | 77 | 72 | ||
| 02/12/2022 | L | 23 | San Francisco (24 - 9) | 58 | 74 | ||
| 02/17/2022 | W | at | 226 | Loyola Marymount (11 - 18) | 84 | 80 | |
| 02/19/2022 | L | at | 1 | Gonzaga (26 - 3) | 69 | 81 | |
| 02/24/2022 | W | at | 325 | Pepperdine (7 - 25) | 89 | 73 | |
| 02/26/2022 | W | 177 | Portland (18 - 14) | 102 | 89 | ||
| 03/05/2022 | W | 177 | Portland (18 - 14) | 91 | 67 | Paradise, NV | |
| 03/07/2022 | L | at | 11 | Saint Mary's (25 - 7) | 72 | 75 | Paradise, NV |