| Team: | Cal Poly | Rating: | -7.963 | Average Socre: | 61.4643 |
| Conference: | Big West | ||||
| Wins: | 7 | Losses: | 21 | Div 1 Games: | 27 |
| Date | Rnk | Team | Location | ||||
| 11/09/2021 | W | Westcliff ( - ) | 86 | 53 | |||
| 11/12/2021 | L | 88 | North Dakota St. (23 - 10) | 57 | 60 | ||
| 11/15/2021 | L | 288 | Sacramento St. (11 - 18) | 57 | 58 | ||
| 11/19/2021 | L | at | 64 | Santa Clara (21 - 11) | 57 | 87 | |
| 11/22/2021 | L | at | 152 | Nicholls St. (21 - 11) | 72 | 75 | San Juan Capistrano, CA |
| 11/24/2021 | W | at | 313 | Idaho (9 - 22) | 67 | 63 | San Juan Capistrano, CA |
| 12/02/2021 | L | at | 206 | Cal Baptist (18 - 15) | 55 | 64 | |
| 12/05/2021 | L | at | 219 | San Diego (15 - 16) | 51 | 52 | |
| 12/11/2021 | W | at | 259 | Portland St. (14 - 17) | 61 | 58 | |
| 12/13/2021 | L | at | 177 | Portland (18 - 14) | 77 | 78 | |
| 12/17/2021 | L | at | 135 | Fresno St. (19 - 13) | 48 | 83 | |
| 01/08/2022 | L | at | 309 | Cal St. Northridge (7 - 23) | 55 | 68 | |
| 01/13/2022 | L | 162 | UC Riverside (16 - 12) | 46 | 57 | ||
| 01/15/2022 | W | 200 | UC Davis (13 - 11) | 82 | 74 | ||
| 01/18/2022 | L | at | 308 | Cal St. Bakersfield (8 - 19) | 60 | 73 | |
| 01/22/2022 | L | 165 | Hawaii (17 - 11) | 56 | 69 | ||
| 01/27/2022 | W | at | 255 | UC San Diego (13 - 16) | 59 | 55 | |
| 01/29/2022 | L | at | 146 | UC Irvine (15 - 10) | 48 | 72 | |
| 02/03/2022 | L | at | 119 | Cal St. Fullerton (21 - 10) | 50 | 61 | |
| 02/05/2022 | L | at | 104 | Long Beach St. (20 - 12) | 65 | 78 | |
| 02/10/2022 | L | 309 | Cal St. Northridge (7 - 23) | 78 | 83 | ||
| 02/12/2022 | L | 171 | UC Santa Barbara (17 - 11) | 64 | 69 | ||
| 02/19/2022 | L | at | 162 | UC Riverside (16 - 12) | 58 | 78 | |
| 02/22/2022 | L | 308 | Cal St. Bakersfield (8 - 19) | 60 | 61 | ||
| 02/24/2022 | L | at | 165 | Hawaii (17 - 11) | 54 | 63 | |
| 03/03/2022 | W | 146 | UC Irvine (15 - 10) | 65 | 54 | ||
| 03/05/2022 | W | 255 | UC San Diego (13 - 16) | 80 | 76 | ||
| 03/08/2022 | L | at | 200 | UC Davis (13 - 11) | 53 | 63 | Henderson, NV |